{"id":252,"date":"2024-09-26T19:32:46","date_gmt":"2024-09-26T13:47:46","guid":{"rendered":"https:\/\/hthakuri.com.np\/blog\/2024\/09\/26\/ige-%e0%a4%ae%e0%a4%a7%e0%a5%8d%e0%a4%af%e0%a4%b8%e0%a5%8d%e0%a4%a5-%e0%a4%96%e0%a4%be%e0%a4%a8%e0%a4%be-%e0%a4%8f%e0%a4%b2%e0%a4%b0%e0%a5%8d%e0%a4%9c%e0%a5%80-%e0%a4%95%e0%a4%b8%e0%a4%b0%e0%a5%80\/"},"modified":"2024-09-26T19:32:46","modified_gmt":"2024-09-26T13:47:46","slug":"ige-%e0%a4%ae%e0%a4%a7%e0%a5%8d%e0%a4%af%e0%a4%b8%e0%a5%8d%e0%a4%a5-%e0%a4%96%e0%a4%be%e0%a4%a8%e0%a4%be-%e0%a4%8f%e0%a4%b2%e0%a4%b0%e0%a5%8d%e0%a4%9c%e0%a5%80-%e0%a4%95%e0%a4%b8%e0%a4%b0%e0%a5%80","status":"publish","type":"post","link":"https:\/\/hthakuri.com.np\/blog\/2024\/09\/26\/ige-%e0%a4%ae%e0%a4%a7%e0%a5%8d%e0%a4%af%e0%a4%b8%e0%a5%8d%e0%a4%a5-%e0%a4%96%e0%a4%be%e0%a4%a8%e0%a4%be-%e0%a4%8f%e0%a4%b2%e0%a4%b0%e0%a5%8d%e0%a4%9c%e0%a5%80-%e0%a4%95%e0%a4%b8%e0%a4%b0%e0%a5%80\/","title":{"rendered":"IgE- \u092e\u0927\u094d\u092f\u0938\u094d\u0925 \u0916\u093e\u0928\u093e \u090f\u0932\u0930\u094d\u091c\u0940 \u0915\u0938\u0930\u0940 \u0928\u093f\u0926\u093e\u0928 \u0917\u0930\u094d\u0928\u0947"},"content":{"rendered":"<p><\/p>\n<div><span class=\"highwire-journal-article-marker-start\"\/><\/p>\n<div class=\"section intro\" id=\"sec-1\">\n<h2 class=\"\">\u092a\u0930\u093f\u091a\u092f<\/h2>\n<p id=\"p-3\">\u092a\u094d\u0930\u0924\u093f\u0915\u0942\u0932 \u0916\u093e\u0926\u094d\u092f \u092a\u094d\u0930\u0924\u093f\u0915\u094d\u0930\u093f\u092f\u093e\u0939\u0930\u0942\u0932\u093e\u0908 \u0935\u094d\u092f\u093e\u092a\u0915 \u0930\u0942\u092a\u092e\u093e \u092a\u094d\u0930\u0924\u093f\u0930\u0915\u094d\u0937\u093e-\u092e\u0927\u094d\u092f\u0938\u094d\u0925\u0924\u093e \u0930 \u0917\u0948\u0930-\u092a\u094d\u0930\u0924\u093f\u0930\u0915\u094d\u0937\u093e-\u092e\u0927\u094d\u092f\u0938\u094d\u0925\u0924\u093e \u092a\u094d\u0930\u0924\u093f\u0915\u094d\u0930\u093f\u092f\u093e\u0939\u0930\u0942\u092e\u093e \u0935\u0930\u094d\u0917\u0940\u0915\u0943\u0924 \u0917\u0930\u094d\u0928 \u0938\u0915\u093f\u0928\u094d\u091b, \u0936\u093e\u0938\u094d\u0924\u094d\u0930\u0940\u092f \u0916\u093e\u0926\u094d\u092f \u090f\u0932\u0930\u094d\u091c\u0940 \u092a\u094d\u0930\u0924\u093f\u0930\u0915\u094d\u0937\u093e \u092e\u0927\u094d\u092f\u0938\u094d\u0925\u0924\u093e\u0915\u094b \u0938\u093e\u0925\u0964<a id=\"xref-ref-1-1\" class=\"xref-bibr\" href=\"#ref-1\">\u0967<\/a> \u0907\u092e\u094d\u092f\u0941\u0928\u094b\u0917\u094d\u0932\u094b\u092c\u0941\u0932\u093f\u0928 \u0908 (IgE) &#8211; \u092e\u0927\u094d\u092f\u0938\u094d\u0925 \u0916\u093e\u0928\u093e \u090f\u0932\u0930\u094d\u091c\u0940 \u090f\u0915 \u092a\u094d\u0930\u0924\u093f\u0930\u0915\u094d\u0937\u093e \u092a\u094d\u0930\u0924\u093f\u0915\u094d\u0930\u093f\u092f\u093e \u0939\u094b \u091c\u0941\u0928 \u0916\u093e\u0928\u093e \u092a\u094d\u0930\u094b\u091f\u0940\u0928\u0915\u094b \u0938\u0902\u092a\u0930\u094d\u0915\u092e\u093e \u0939\u0941\u0928\u094d\u091b\u0964<a id=\"xref-ref-2-1\" class=\"xref-bibr\" href=\"#ref-2\">\u0968<\/a> \u0932\u0915\u094d\u0937\u0923\u0939\u0930\u0942\u092e\u093e urticaria, angioedema, \u0935\u093e\u0928\u094d\u0924\u093e, \u092a\u0947\u091f \u0926\u0941\u0916\u094d\u0928\u0947, \u092a\u0916\u093e\u0932\u093e, \u0924\u0940\u0935\u094d\u0930 rhinoconjunctivitis, \u0918\u0930\u0918\u0930\u093e\u0939\u091f, \u0916\u094b\u0915\u0940, \u0938\u094d\u091f\u094d\u0930\u093f\u0921\u0930, \u0939\u093e\u0907\u092a\u094b\u091f\u0947\u0928\u094d\u0938\u0928 \u0930 \u0939\u0943\u0926\u092f\u093e\u0918\u093e\u0924 \u0938\u092e\u093e\u0935\u0947\u0936 \u0939\u0941\u0928 \u0938\u0915\u094d\u091b\u0964<a id=\"xref-ref-2-2\" class=\"xref-bibr\" href=\"#ref-2\">\u0968<\/a> \u092f\u0926\u094d\u092f\u092a\u093f \u0935\u094d\u092f\u093e\u092a\u0915\u0924\u093e \u0921\u0947\u091f\u093e \u0938\u093e\u092e\u093e\u0928\u094d\u092f\u0924\u092f\u093e \u0906\u0924\u094d\u092e-\u0930\u093f\u092a\u094b\u0930\u094d\u091f\u093f\u0919 \u0926\u094d\u0935\u093e\u0930\u093e \u091c\u091f\u093f\u0932 \u0939\u0941\u0928\u094d\u091b (\u091c\u0938\u0932\u0947 \u0905\u0927\u093f\u0915-\u0930\u093f\u092a\u094b\u0930\u094d\u091f\u093f\u0919 \u0924\u093f\u0930 \u091d\u0941\u0915\u093e\u0909\u0901\u091b), \u092a\u0936\u094d\u091a\u093f\u092e\u0940 \u0926\u0947\u0936\u0939\u0930\u0942\u092e\u093e \u226410% \u092d\u0928\u094d\u0926\u093e \u0915\u092e \u0909\u092e\u0947\u0930\u0915\u093e \u092c\u093e\u0932\u092c\u093e\u0932\u093f\u0915\u093e\u0939\u0930\u0942\u092e\u093e IgE-\u092e\u0927\u094d\u092f\u0938\u094d\u0925\u0924\u093e \u0916\u093e\u0928\u093e \u090f\u0932\u0930\u094d\u091c\u0940\u0915\u094b \u092a\u094d\u0930\u0938\u093e\u0930 \u0905\u0928\u0941\u092e\u093e\u0928 \u0917\u0930\u093f\u090f\u0915\u094b \u091b\u0964<a id=\"xref-ref-3-1\" class=\"xref-bibr\" href=\"#ref-3\">\u0969<\/a> \u0935\u093f\u0917\u0924 \u0926\u0936\u0915\u092e\u093e, \u0905\u0927\u093f\u0915\u093e\u0902\u0936 \u0926\u0947\u0936\u0939\u0930\u0942\u0932\u0947 IgE- \u092e\u0927\u094d\u092f\u0938\u094d\u0925\u0924\u093e\u092f\u0941\u0915\u094d\u0924 \u0916\u093e\u0928\u093e \u090f\u0932\u0930\u094d\u091c\u0940\u0915\u094b \u092a\u094d\u0930\u091a\u0932\u0928\u092e\u093e \u0935\u0943\u0926\u094d\u0927\u093f \u092d\u090f\u0915\u094b \u0930\u093f\u092a\u094b\u0930\u094d\u091f \u0917\u0930\u0947\u0915\u093e \u091b\u0928\u094d, \u0915\u0941\u0928\u0948 \u092a\u0928\u093f \u092a\u0936\u094d\u091a\u093f\u092e\u0940 \u0926\u0947\u0936\u0939\u0930\u0942\u0932\u0947 \u0918\u091f\u0947\u0915\u094b \u0930\u093f\u092a\u094b\u0930\u094d\u091f \u0917\u0930\u0947\u0915\u093e \u091b\u0948\u0928\u0928\u094d\u0964<a id=\"xref-ref-3-2\" class=\"xref-bibr\" href=\"#ref-3\">\u0969<\/a>\n<\/p>\n<p id=\"p-4\">\u0939\u093e\u0932, IgE-\u092e\u0927\u094d\u092f\u0938\u094d\u0925\u0924\u093e \u092b\u0942\u0921 \u090f\u0932\u0930\u094d\u091c\u0940\u0915\u094b \u0928\u093f\u0926\u093e\u0928 \u0917\u0930\u094d\u0928\u0947 \u0935\u094d\u092f\u093e\u092a\u0915 \u0930\u0942\u092a\u092e\u093e \u0938\u094d\u0935\u0940\u0915\u0943\u0924 \u092a\u094d\u0930\u0915\u094d\u0930\u093f\u092f\u093e\u092e\u093e \u092a\u0941\u0937\u094d\u091f\u093f\u0915\u0930\u0923 \u092a\u0930\u0940\u0915\u094d\u0937\u0923\u0926\u094d\u0935\u093e\u0930\u093e \u0938\u092e\u0930\u094d\u0925\u093f\u0924 \u0938\u091f\u0940\u0915 \u0930 \u092a\u0942\u0930\u094d\u0923 \u0907\u0924\u093f\u0939\u093e\u0938 \u0938\u092e\u093e\u0935\u0947\u0936 \u091b\u0964<a id=\"xref-ref-4-1\" class=\"xref-bibr\" href=\"#ref-4\">\u096a<\/a> \u092f\u0940 \u092a\u0941\u0937\u094d\u091f\u093f \u092a\u0930\u0940\u0915\u094d\u0937\u0923\u0939\u0930\u0942\u092e\u093e \u0915\u092e\u091c\u094b\u0930 \u0935\u093f\u0936\u093f\u0937\u094d\u091f\u0924\u093e \u0939\u0941\u0928 \u0938\u0915\u094d\u091b, \u0917\u092e\u094d\u092d\u0940\u0930 \u090f\u0932\u0930\u094d\u091c\u0940 \u092a\u094d\u0930\u0924\u093f\u0915\u094d\u0930\u093f\u092f\u093e\u0939\u0930\u0942\u0915\u094b \u092c\u0922\u094d\u0926\u094b 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id=\"xref-ref-5-1\" class=\"xref-bibr\" href=\"#ref-5\">\u096b \u096c<\/a> \u0925\u092a \u0930\u0942\u092a\u092e\u093e, \u092c\u093e\u092f\u094b\u092e\u093e\u0930\u094d\u0915\u0930\u0939\u0930\u0942 \u091c\u0938\u0932\u0947 \u0928\u093f\u0926\u093e\u0928\u0915\u094b \u092d\u0935\u093f\u0937\u094d\u092f\u0935\u093e\u0923\u0940 \u0917\u0930\u094d\u0926\u091b, \u090f\u0932\u0930\u094d\u091c\u0940\u0928 \u0925\u094d\u0930\u0947\u0938\u0939\u094b\u0932\u094d\u0921\u0939\u0930\u0942 \u092a\u0939\u093f\u091a\u093e\u0928 \u0917\u0930\u094d\u0926\u091b, \u0930\u094b\u0917\u0915\u094b \u0917\u092e\u094d\u092d\u0940\u0930\u0924\u093e\/\u0930\u093f\u091c\u094b\u0932\u094d\u092f\u0941\u0936\u0928 \u0928\u093f\u0917\u0930\u093e\u0928\u0940 \u0917\u0930\u094d\u0926\u091b \u0930 \u0909\u092a\u091a\u093e\u0930 \u0928\u093f\u0930\u094d\u0923\u092f\u0939\u0930\u0942 \u0905\u091d \u0938\u0939\u0940 \u0930\u0942\u092a\u092e\u093e \u0938\u0942\u091a\u093f\u0924 \u0917\u0930\u094d\u0926\u091b\u0964<\/p>\n<p id=\"p-5\">\u0938\u094d\u0935\u093e\u0938\u094d\u0925\u094d\u092f \u0938\u0947\u0935\u093e \u092a\u094d\u0930\u0926\u093e\u092f\u0915\u0939\u0930\u0942 (HCPs) \u0932\u093e\u0908 \u092a\u0930\u0940\u0915\u094d\u0937\u0923\u0939\u0930\u0942 \u0909\u091a\u093f\u0924 \u0930\u0942\u092a\u092e\u093e \u092a\u094d\u0930\u092f\u094b\u0917 \u0917\u0930\u094d\u0928 \u0930 \u0938\u0942\u091a\u093f\u0924 \u0915\u094d\u0932\u093f\u0928\u093f\u0915\u0932 \u092e\u093e\u0930\u094d\u0917\u0926\u0930\u094d\u0936\u0928 \u092a\u094d\u0930\u0926\u093e\u0928 \u0917\u0930\u094d\u0928\u0915\u093e \u0932\u093e\u0917\u093f, \u0935\u093f\u0936\u093f\u0937\u094d\u091f\u0924\u093e, \u0938\u0902\u0935\u0947\u0926\u0928\u0936\u0940\u0932\u0924\u093e, \u0938\u0915\u093e\u0930\u093e\u0924\u094d\u092e\u0915 \u092d\u0935\u093f\u0937\u094d\u092f\u0935\u093e\u0923\u0940 \u092e\u093e\u0928 (PPV) \u0930 \u0928\u0915\u093e\u0930\u093e\u0924\u094d\u092e\u0915 \u092d\u0935\u093f\u0937\u094d\u092f\u0935\u093e\u0923\u0940\u0915\u094b \u092c\u0941\u091d\u093e\u0907\u0915\u094b \u0938\u093e\u0925\u0938\u093e\u0925\u0948 IgE- \u092e\u0927\u094d\u092f\u0938\u094d\u0925 \u0916\u093e\u0928\u093e \u090f\u0932\u0930\u094d\u091c\u0940\u0915\u094b \u0932\u093e\u0917\u093f \u0915\u0941\u0928 \u092c\u093f\u0930\u093e\u092e\u0940\u0932\u093e\u0908 \u092a\u0930\u0940\u0915\u094d\u0937\u0923 \u0917\u0930\u094d\u0928\u0947 \u092d\u0928\u094d\u0928\u0947 \u092c\u093e\u0930\u0947 \u0938\u091a\u0947\u0924\u0928\u093e \u092c\u0922\u093e\u0909\u0928 \u0906\u0935\u0936\u094d\u092f\u0915 \u091b\u0964 \u092f\u0940 \u092a\u0930\u0940\u0915\u094d\u0937\u0923\u0939\u0930\u0942\u0915\u094b \u092e\u0942\u0932\u094d\u092f\u0964 IgE-\u092e\u0927\u094d\u092f\u0938\u094d\u0925\u0924\u093e \u092b\u0942\u0921 \u090f\u0932\u0930\u094d\u091c\u0940 \u092a\u0930\u0940\u0915\u094d\u0937\u0923\u0915\u094b \u0905\u0924\u094d\u092f\u0927\u093f\u0915 \u092a\u094d\u0930\u092f\u094b\u0917\u0932\u0947 \u0938\u092e\u094d\u092d\u0935\u0924\u0903 \u0905\u0924\u094d\u092f\u0927\u093f\u0915 \u0928\u093f\u0926\u093e\u0928 \u0909\u0924\u094d\u092a\u0928\u094d\u0928 \u0917\u0930\u094d\u0926\u091b, \u091c\u0938\u0932\u0947 \u0905\u0928\u093e\u0935\u0936\u094d\u092f\u0915 \u0906\u0939\u093e\u0930 \u092a\u094d\u0930\u0924\u093f\u092c\u0928\u094d\u0927 \u0930 \u092e\u0928\u094b\u0938\u093e\u092e\u093e\u091c\u093f\u0915 \u0930 \u0906\u0930\u094d\u0925\u093f\u0915 \u092c\u094b\u091d \u0928\u093f\u092e\u094d\u0924\u094d\u092f\u093e\u0909\u0901\u091b\u0964 \u092f\u0939\u093e\u0901, \u0939\u093e\u092e\u0940 IgE-\u092e\u0927\u094d\u092f\u0938\u094d\u0925\u0924\u093e \u0916\u093e\u0928\u093e \u090f\u0932\u0930\u094d\u091c\u0940, \u0909\u092a\u092f\u0941\u0915\u094d\u0924 \u092a\u0930\u093f\u0923\u093e\u092e \u0935\u094d\u092f\u093e\u0916\u094d\u092f\u093e \u0930 \u0905\u0924\u093f \u092a\u0930\u0940\u0915\u094d\u0937\u0923 \u091c\u094b\u0916\u093f\u092e\u0939\u0930\u0942\u0915\u094b \u0928\u093f\u0926\u093e\u0928\u0915\u094b \u0932\u093e\u0917\u093f \u0926\u0943\u0937\u094d\u091f\u093f\u0915\u094b\u0923\u0939\u0930\u0942 \u0938\u0902\u0915\u094d\u0937\u0947\u092a \u0917\u0930\u094d\u0926\u091b\u094c\u0902\u0964<\/p>\n<\/div>\n<div class=\"section\" id=\"sec-2\">\n<h2 class=\"\">IgE-\u092e\u0927\u094d\u092f\u0938\u094d\u0925\u0924\u093e \u0916\u093e\u0928\u093e \u090f\u0932\u0930\u094d\u091c\u0940\u0915\u094b \u0932\u093e\u0917\u093f \u0939\u093e\u0932\u0915\u094b \u092a\u0930\u0940\u0915\u094d\u0937\u0923 \u0926\u093f\u0936\u093e\u0928\u093f\u0930\u094d\u0926\u0947\u0936\u0939\u0930\u0942<\/h2>\n<p id=\"p-6\">\u090f\u0932\u0930\u094d\u091c\u0940 \u092a\u0930\u0940\u0915\u094d\u0937\u0923\u0915\u094b \u0906\u0935\u0936\u094d\u092f\u0915\u0924\u093e \u0928\u093f\u0930\u094d\u0927\u093e\u0930\u0923 \u0917\u0930\u094d\u0928 \u0930 \u0938\u092c\u0948\u092d\u0928\u094d\u0926\u093e \u0938\u091f\u0940\u0915 \u092a\u0930\u0940\u0915\u094d\u0937\u0923 \u0935\u093f\u0927\u093f\u0939\u0930\u0942 \u092a\u0939\u093f\u091a\u093e\u0928 \u0917\u0930\u094d\u0928 \u0938\u093e\u0928\u094d\u0926\u0930\u094d\u092d\u093f\u0915 \u0928\u093f\u0926\u093e\u0928\u0939\u0930\u0942 \u0917\u0930\u094d\u0928 \u092e\u0939\u0924\u094d\u0924\u094d\u0935\u092a\u0942\u0930\u094d\u0923 \u091b, \u0938\u093e\u0925\u0948 \u0905\u0924\u093f \u092a\u0930\u0940\u0915\u094d\u0937\u0923 \u0930 \u0905\u0927\u093f\u0915 \u0928\u093f\u0926\u093e\u0928\u0932\u093e\u0908 \u0938\u0940\u092e\u093f\u0924 \u0917\u0930\u094d\u0928\u0964 \u0938\u0902\u092f\u0941\u0915\u094d\u0924 \u0930\u093e\u091c\u094d\u092f \u0905\u092e\u0947\u0930\u093f\u0915\u093e \u0930 \u092f\u0941\u0930\u094b\u092a\u0915\u093e \u0926\u093f\u0936\u093e\u0928\u093f\u0930\u094d\u0926\u0947\u0936\u0939\u0930\u0942\u0932\u0947 \u090f\u0932\u0930\u094d\u091c\u0940 \u092a\u094d\u0930\u0924\u093f\u0915\u094d\u0930\u093f\u092f\u093e\u0939\u0930\u0942 \u0928\u093f\u092e\u094d\u0924\u094d\u092f\u093e\u0909\u0928\u0947 \u0936\u0902\u0915\u093e\u0938\u094d\u092a\u0926 \u0916\u093e\u0928\u093e\u0939\u0930\u0942\u092e\u093e \u0927\u094d\u092f\u093e\u0928 \u0915\u0947\u0928\u094d\u0926\u094d\u0930\u093f\u0924 \u0917\u0930\u094d\u0928\u0947 \u092a\u094d\u0930\u093e\u0938\u0902\u0917\u093f\u0915 \u091a\u093f\u0915\u093f\u0924\u094d\u0938\u093e \u0907\u0924\u093f\u0939\u093e\u0938 \u092d\u090f\u0915\u093e \u092c\u093f\u0930\u093e\u092e\u0940\u0939\u0930\u0942\u092e\u093e \u0935\u093f\u0936\u093f\u0937\u094d\u091f IgE \u092a\u0930\u0940\u0915\u094d\u0937\u0923\u0939\u0930\u0942 \u0938\u093f\u092b\u093e\u0930\u093f\u0938 \u0917\u0930\u094d\u0926\u091b\u0964<a id=\"xref-ref-2-3\" class=\"xref-bibr\" href=\"#ref-2\">\u0968 \u096a \u096d<\/a> \u0935\u093f\u0936\u093f\u0937\u094d\u091f IgE \u092a\u0930\u0940\u0915\u094d\u0937\u0923 \u0928\u0924\u093f\u091c\u093e\u0939\u0930\u0942 \u092e\u093e\u0924\u094d\u0930 IgE-\u092e\u0927\u094d\u092f\u0938\u094d\u0925\u0924\u093e \u0916\u093e\u0928\u093e \u090f\u0932\u0930\u094d\u091c\u0940\u0915\u094b \u0928\u093f\u0926\u093e\u0928 \u092e\u093e\u0928\u093f\u0928\u0947 \u091b\u0948\u0928\u0928\u094d (\u0905\u0930\u094d\u0925\u093e\u0924, \u0924\u093f\u0928\u0940\u0939\u0930\u0942\u0932\u0947 \u0938\u0902\u0935\u0947\u0926\u0928\u0936\u0940\u0932\u0924\u093e \u0938\u0902\u0915\u0947\u0924 \u0917\u0930\u094d\u091b\u0928\u094d \u0930 \u0915\u094d\u0932\u093f\u0928\u093f\u0915\u0932 \u0907\u0924\u093f\u0939\u093e\u0938\u0915\u094b \u0938\u093e\u0925 \u0935\u093f\u091a\u093e\u0930 \u0917\u0930\u094d\u0928\u0941\u092a\u0930\u094d\u091b)\u0964<a id=\"xref-ref-4-3\" class=\"xref-bibr\" href=\"#ref-4\">\u096a<\/a> \u092f\u0926\u093f \u0928\u0948\u0926\u093e\u0928\u093f\u0915 \u200b\u200b\u200b\u200b\u0907\u0924\u093f\u0939\u093e\u0938 \u0930 IgE \u092a\u0930\u0940\u0915\u094d\u0937\u0923\u0939\u0930\u0942 \u0909\u091a\u094d\u091a \u0905\u0928\u0941\u092e\u093e\u0928\u093f\u0924 \u091b\u0948\u0928\u0928\u094d \u092d\u0928\u0947, \u090f\u0915 \u092e\u094c\u0916\u093f\u0915 \u0916\u093e\u0928\u093e \u091a\u0941\u0928\u094c\u0924\u0940 (OFC) \u0938\u093f\u092b\u093e\u0930\u093f\u0938 \u0917\u0930\u093f\u0928\u094d\u091b\u0964<a id=\"xref-ref-4-4\" class=\"xref-bibr\" href=\"#ref-4\">\u096a \u096d<\/a> \u0938\u093f\u092b\u093e\u0930\u093f\u0938 \u0917\u0930\u093f\u090f\u0915\u094b \u0916\u093e\u0928\u093e-\u0935\u093f\u0936\u093f\u0937\u094d\u091f IgE \u092a\u0930\u0940\u0915\u094d\u0937\u0923\u0939\u0930\u0942 \u0930 OFCs \u0915\u094b \u0935\u093f\u0936\u0947\u0937\u0924\u093e\u0939\u0930\u0942 \u0935\u093f\u0938\u094d\u0924\u0943\u0924 \u0930\u0942\u092a\u092e\u093e \u091b\u0928\u094d <a id=\"xref-table-wrap-1-1\" class=\"xref-table\" href=\"#T1\">\u0924\u093e\u0932\u093f\u0915\u093e \u0967<\/a>\u0964<a id=\"xref-ref-2-4\" class=\"xref-bibr\" href=\"#ref-2\">\u0968 \u096a \u096e<\/a>\n<\/p>\n<div id=\"T1\" class=\"table pos-float\">\n<div class=\"table-caption\"><span class=\"table-label\">\u0924\u093e\u0932\u093f\u0915\u093e \u0967<\/span> <\/p>\n<p id=\"p-7\" class=\"first-child\">\u0916\u093e\u0928\u093e \u090f\u0932\u0930\u094d\u091c\u0940\u0928 \u092a\u0930\u0940\u0915\u094d\u0937\u0923 \u0915\u094b \u0935\u093f\u0936\u0947\u0937\u0924\u093e\u0939\u0930\u0941<a id=\"xref-ref-2-5\" class=\"xref-bibr\" href=\"#ref-2\">\u0968 \u096a \u096e<\/a>\n<\/p>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"section\" id=\"sec-3\">\n<h2 class=\"\">\u091a\u093f\u0915\u093f\u0924\u094d\u0938\u093e \u0907\u0924\u093f\u0939\u093e\u0938 \u0915\u094b \u092e\u0939\u0924\u094d\u0935<\/h2>\n<p id=\"p-10\">\u0926\u093f\u0936\u093e\u0928\u093f\u0930\u094d\u0926\u0947\u0936\u0939\u0930\u0942 \u0938\u0939\u092e\u0924 \u091b\u0928\u094d \u0915\u093f \u091a\u093f\u0915\u093f\u0924\u094d\u0938\u093e \u0907\u0924\u093f\u0939\u093e\u0938 \u092a\u094d\u0930\u093e\u092a\u094d\u0924 \u0917\u0930\u094d\u0928\u0941 IgE- \u092e\u0927\u094d\u092f\u0938\u094d\u0925 \u0916\u093e\u0928\u093e \u090f\u0932\u0930\u094d\u091c\u0940\u0915\u094b \u0928\u093f\u0926\u093e\u0928\u092e\u093e \u0938\u092c\u0948\u092d\u0928\u094d\u0926\u093e \u092e\u0939\u0924\u094d\u0924\u094d\u0935\u092a\u0942\u0930\u094d\u0923 \u091a\u0930\u0923 \u0939\u094b\u0964<a id=\"xref-ref-2-6\" class=\"xref-bibr\" href=\"#ref-2\">\u0968 \u096d \u096f<\/a> \u092e\u0947\u0921\u093f\u0915\u0932 \u0908\u0924\u093f\u0939\u093e\u0938\u0932\u0947 \u092c\u093f\u0930\u093e\u092e\u0940\u0915\u094b IgE-\u092e\u0927\u094d\u092f\u0938\u094d\u0925\u0924\u093e \u092a\u094d\u0930\u0924\u093f\u0915\u094d\u0930\u093f\u092f\u093e \u092d\u090f\u0915\u094b \u092a\u094d\u0930\u093e\u0930\u092e\u094d\u092d\u093f\u0915 \u0938\u092e\u094d\u092d\u093e\u0935\u094d\u092f\u0924\u093e \u0928\u093f\u0930\u094d\u0927\u093e\u0930\u0923 \u0917\u0930\u094d\u0928\u0947\u091b \u0930 \u0932\u0915\u094d\u0937\u0923\u0939\u0930\u0942, \u091a\u093f\u0928\u094d\u0924\u093e\u0915\u094b \u0916\u093e\u0928\u093e \u0930 \u0935\u094d\u092f\u093e\u092f\u093e\u092e \u0935\u093e \u0914\u0937\u0927\u093f\u0939\u0930\u0942 \u0938\u0939\u093f\u0924 \u0938\u092e\u093e\u0935\u0947\u0936 \u0939\u0941\u0928 \u0938\u0915\u094d\u0928\u0947 \u0905\u0928\u094d\u092f \u0915\u093e\u0930\u0915\u0939\u0930\u0942\u0915\u094b \u092c\u093e\u0930\u0947\u092e\u093e \u0938\u094b\u0927\u0947\u0930 \u092a\u0930\u0940\u0915\u094d\u0937\u0923 \u0935\u093e\u0930\u0947\u0928\u094d\u091f\u0940 \u091b \u0915\u093f \u091b\u0948\u0928 \u092d\u0928\u0947\u0930 \u092a\u0924\u094d\u0924\u093e \u0932\u0917\u093e\u0909\u0928 \u092e\u0926\u094d\u0926\u0924 \u0917\u0930\u094d\u0928\u0947\u091b\u0964<a id=\"xref-ref-4-5\" class=\"xref-bibr\" href=\"#ref-4\">\u096a<\/a> \u0936\u093e\u0930\u0940\u0930\u093f\u0915 \u092a\u0930\u0940\u0915\u094d\u0937\u0923\u0932\u0947 \u0938\u092e\u094d\u092d\u093e\u0935\u093f\u0924 \u0915\u092e\u094b\u0930\u092c\u093f\u0921\u093f\u091f\u0940\u0939\u0930\u0942 (\u091c\u0938\u094d\u0924\u0948, \u090f\u091f\u094b\u092a\u093f\u0915 \u0921\u0930\u094d\u092e\u0947\u091f\u093e\u0907\u091f\u093f\u0938) \u092a\u0939\u093f\u091a\u093e\u0928 \u0917\u0930\u094d\u0928 \u0938\u0915\u094d\u091b \u091c\u0938\u0932\u0947 IgE- \u092e\u0927\u094d\u092f\u0938\u094d\u0925\u0924\u093e\u092e\u093e \u090f\u0932\u0930\u094d\u091c\u0940\u0932\u093e\u0908 \u092c\u0922\u0940 \u0938\u092e\u094d\u092d\u093e\u0935\u093f\u0924 \u092c\u0928\u093e\u0909\u0928\u0947\u091b\u0964<a id=\"xref-ref-4-6\" class=\"xref-bibr\" href=\"#ref-4\">\u096a<\/a> IgE- \u092e\u0927\u094d\u092f\u0938\u094d\u0925 \u0916\u093e\u0928\u093e \u090f\u0932\u0930\u094d\u091c\u0940 \u0938\u0902\u0917 \u0938\u0902\u0917\u0924 \u0907\u0924\u093f\u0939\u093e\u0938 \u092d\u090f\u0915\u093e \u092c\u093f\u0930\u093e\u092e\u0940\u0939\u0930\u0942\u0932\u093e\u0908 \u0938\u093e\u092e\u093e\u0928\u094d\u092f\u0924\u092f\u093e \u091b\u093e\u0932\u093e \u091a\u0941\u092e\u094d\u092c\u0928 \u092a\u0930\u0940\u0915\u094d\u0937\u0923 (SPT), \u0938\u0940\u0930\u092e \u090f\u0928\u094d\u091f\u093f\u091c\u0947\u0928-\u0935\u093f\u0936\u093f\u0937\u094d\u091f IgE (sIgE) \u0938\u094d\u0924\u0930\u0939\u0930\u0942\u0915\u094b \u092e\u093e\u092a\u0928 \u0935\u093e \u0926\u0941\u092c\u0948 \u0926\u094d\u0935\u093e\u0930\u093e \u092e\u0942\u0932\u094d\u092f\u093e\u0919\u094d\u0915\u0928 \u0917\u0930\u093f\u0928\u094d\u091b\u0964<a id=\"xref-ref-4-7\" class=\"xref-bibr\" href=\"#ref-4\">\u096a<\/a>\n<\/p>\n<p id=\"p-11\">\u092f\u0938\u0915\u094b \u0935\u093f\u092a\u0930\u093f\u0924, IgE- \u092e\u0927\u094d\u092f\u0938\u094d\u0925 \u0916\u093e\u0928\u093e \u090f\u0932\u0930\u094d\u091c\u0940\u0915\u094b \u0938\u0941\u091d\u093e\u0935 \u0928\u0926\u093f\u0928\u0947 \u0907\u0924\u093f\u0939\u093e\u0938 \u092d\u090f\u0915\u093e \u092c\u093f\u0930\u093e\u092e\u0940\u0939\u0930\u0942\u0932\u0947 \u0925\u092a \u092a\u0930\u0940\u0915\u094d\u0937\u0923\u0939\u0930\u0942\u092c\u093e\u091f \u0917\u0941\u091c\u094d\u0930\u0928\u0941 \u0939\u0941\u0901\u0926\u0948\u0928,<a id=\"xref-ref-2-7\" class=\"xref-bibr\" href=\"#ref-2\">\u0968<\/a> \u0915\u093f\u0928\u0915\u093f \u092f\u0940 \u092a\u0930\u0940\u0915\u094d\u0937\u0923\u0939\u0930\u0942\u0932\u0947 \u0905\u0938\u0939\u093f\u0937\u094d\u0923\u0941\u0924\u093e \u0935\u093e \u0916\u093e\u0928\u093e\u0939\u0930\u0942\u092e\u093e \u0905\u0928\u094d\u092f \u092a\u094d\u0930\u0924\u093f\u0930\u0915\u094d\u0937\u093e \u092a\u094d\u0930\u0924\u093f\u0915\u094d\u0930\u093f\u092f\u093e\u0939\u0930\u0942\u0915\u094b \u091c\u093e\u0901\u091a \u0917\u0930\u094d\u0926\u0948\u0928\u0964<a id=\"xref-ref-4-8\" class=\"xref-bibr\" href=\"#ref-4\">\u096a<\/a> \u0907\u0924\u093f\u0939\u093e\u0938 \u0938\u0941\u091d\u093e\u0935\u093e\u0924\u094d\u092e\u0915 \u0928\u092d\u090f\u0938\u092e\u094d\u092e, \u0938\u093e\u092e\u093e\u0928\u094d\u092f \u090f\u0932\u0930\u094d\u091c\u0940\u0939\u0930\u0942 \u0928\u092d\u090f\u0915\u093e \u0916\u093e\u0928\u093e \u091f\u094d\u0930\u093f\u0917\u0930\u0939\u0930\u0942 \u092a\u0930\u0940\u0915\u094d\u0937\u0923 \u0917\u0930\u094d\u0926\u093e \u0938\u093e\u0935\u0927\u093e\u0928\u0940 \u0906\u0935\u0936\u094d\u092f\u0915 \u091b, \u0915\u093f\u0928\u0915\u093f \u0938\u092c\u0948 \u092a\u094d\u0930\u0924\u093f\u0915\u094d\u0930\u093f\u092f\u093e\u0939\u0930\u0942\u0915\u094b 95% \u0906\u0920 \u090f\u0932\u0930\u094d\u091c\u0940\u0939\u0930\u0942\u092c\u093e\u091f \u0939\u0941\u0928\u094d\u091b, \u0938\u094b\u092f\u093e, \u0917\u0939\u0941\u0901, \u0926\u0942\u0927 \u0930 \u0905\u0923\u094d\u0921\u093e (\u0938\u093e\u0928\u093e \u092c\u091a\u094d\u091a\u093e\u0939\u0930\u0942\u092e\u093e \u092a\u094d\u0930\u091a\u0932\u093f\u0924 \u0930 \u092a\u094d\u0930\u093e\u092f\u0903 \u092c\u093e\u0939\u093f\u0930 \u092c\u0922\u0947\u0915\u094b) \u0938\u0939\u093f\u0924\u0964 \u092e\u0942\u0902\u0917\u092b\u0932\u0940, \u0930\u0942\u0916 \u0928\u091f, \u092e\u093e\u091b\u093e \u0930 \u0915\u094d\u0930\u0938\u094d\u091f\u0947\u0938\u093f\u092f\u0928 \u0936\u0947\u0932\u092b\u093f\u0936 (\u0938\u093e\u092e\u093e\u0928\u094d\u092f\u0924\u092f\u093e \u092c\u093e\u0939\u093f\u0930 \u092c\u0922\u0947\u0915\u094b \u091b\u0948\u0928) \u0915\u094b \u0930\u0942\u092a\u092e\u093e\u0964<a id=\"xref-ref-2-8\" class=\"xref-bibr\" href=\"#ref-2\">\u0968 \u096a \u096f<\/a>\n<\/p>\n<\/div>\n<div class=\"section\" id=\"sec-4\">\n<h2 class=\"\">\u091b\u093e\u0932\u093e \u091a\u0941\u092e\u094d\u092c\u0928 \u092a\u0930\u0940\u0915\u094d\u0937\u0923<\/h2>\n<p id=\"p-12\">SPT \u092e\u093e, \u092a\u094d\u0930\u0936\u094d\u0928\u092e\u093e \u0930\u0939\u0947\u0915\u094b \u092b\u0942\u0921 \u090f\u0928\u094d\u091f\u093f\u091c\u0947\u0928 (\u0938\u093e\u092e\u093e\u0928\u094d\u092f\u0924\u092f\u093e \u090f\u0915 \u0928\u093f\u0915\u093e\u0938\u0940) \u0939\u093e\u0924\u0915\u094b \u092d\u094b\u0932\u0930 \u0938\u0924\u0939\u092e\u093e \u0935\u093e \u092a\u091b\u093e\u0921\u093f\u0915\u094b \u092d\u093e\u0917\u092e\u093e \u0932\u094d\u092f\u093e\u0928\u094d\u0938\u0947\u091f \u0935\u093e \u091b\u093e\u0932\u093e-\u092a\u0930\u0940\u0915\u094d\u0937\u0923 \u0909\u092a\u0915\u0930\u0923\u0915\u094b \u0938\u093e\u0925 \u0930\u093e\u0916\u093f\u0928\u094d\u091b \u091c\u0938\u0932\u0947 \u090f\u092a\u093f\u0921\u0930\u094d\u092e\u093f\u0938\u092e\u093e \u090f\u0928\u094d\u091f\u093f\u091c\u0947\u0928 \u092a\u0930\u093f\u091a\u092f \u0917\u0930\u093e\u0909\u0901\u091b\u0964 \u092f\u0926\u093f \u0930\u094b\u0917\u0940\u0932\u0947 \u0924\u094d\u092f\u094b \u090f\u0928\u094d\u091f\u093f\u091c\u0947\u0928\u092e\u093e IgE \u090f\u0928\u094d\u091f\u093f\u092c\u0921\u0940 \u0935\u093f\u0915\u093e\u0938 \u0917\u0930\u0947\u0915\u094b \u091b \u092d\u0928\u0947, \u0932\u0917\u092d\u0917 15 \u092e\u093f\u0928\u0947\u091f \u092d\u093f\u0924\u094d\u0930 \u090f\u0915 \u0935\u093f\u0932 \u0930 \u092b\u094d\u0932\u0947\u092f\u0930 \u092a\u094d\u0930\u0924\u093f\u0915\u094d\u0930\u093f\u092f\u093e \u0926\u0947\u0916\u093e \u092a\u0930\u094d\u0928\u0947\u091b\u0964 \u092f\u094b \u092a\u094d\u0930\u0924\u093f\u0915\u094d\u0930\u093f\u092f\u093e \u0928\u0915\u093e\u0930\u093e\u0924\u094d\u092e\u0915 \u0928\u093f\u092f\u0928\u094d\u0924\u094d\u0930\u0923 (\u091c\u0938\u094d\u0924\u0948, \u0928\u092e\u0915\u0940\u0928) \u0930 \u0938\u0915\u093e\u0930\u093e\u0924\u094d\u092e\u0915 \u0928\u093f\u092f\u0928\u094d\u0924\u094d\u0930\u0923 (\u091c\u0938\u094d\u0924\u0948, \u0939\u093f\u0938\u094d\u091f\u093e\u092e\u093e\u0907\u0928) \u0938\u0901\u0917 \u0924\u0941\u0932\u0928\u093e \u0917\u0930\u093f\u090f\u0915\u094b \u091b\u0964<a id=\"xref-ref-2-9\" class=\"xref-bibr\" href=\"#ref-2\">\u0968 \u096a<\/a> SPT \u0915\u0938\u0930\u0940 \u092a\u094d\u0930\u0926\u0930\u094d\u0936\u0928 \u0917\u0930\u094d\u0928\u0947 \u0930 \u092a\u0930\u093f\u0923\u093e\u092e\u0939\u0930\u0942 \u0935\u094d\u092f\u093e\u0916\u094d\u092f\u093e \u0917\u0930\u094d\u0928\u0947 \u0939\u093e\u0932\u0948 \u092b\u0947\u0930\u0940\u0938 \u0926\u094d\u0935\u093e\u0930\u093e \u0935\u0930\u094d\u0923\u0928 \u0917\u0930\u093f\u090f\u0915\u094b \u0925\u093f\u092f\u094b <em>et al<\/em>\u0964<a id=\"xref-ref-10-1\" class=\"xref-bibr\" href=\"#ref-10\">\u0967\u0966<\/a>\n<\/p>\n<\/div>\n<div class=\"section\" id=\"sec-5\">\n<h2 class=\"\">sIgE \u092a\u0930\u0940\u0915\u094d\u0937\u0923\u0939\u0930\u0942<\/h2>\n<p id=\"p-13\">sIgE \u092a\u0930\u0940\u0915\u094d\u0937\u0923\u0939\u0930\u0942\u0932\u0947 \u0938\u0902\u0926\u093f\u0917\u094d\u0927 \u090f\u0932\u0930\u094d\u091c\u0940\u0939\u0930\u0942\u0915\u093e \u0932\u093e\u0917\u093f \u092a\u0930\u093f\u0938\u0902\u091a\u0930\u0923 IgE \u090f\u0928\u094d\u091f\u093f\u092c\u0921\u0940\u0939\u0930\u0942 \u092a\u0924\u094d\u0924\u093e \u0932\u0917\u093e\u0909\u0901\u0926\u091b, \u0924\u0930 sIgE \u0938\u094d\u0924\u0930\u0939\u0930\u0942\u0915\u094b \u092d\u0935\u093f\u0937\u094d\u092f\u0935\u093e\u0923\u0940 \u092e\u093e\u0928 \u092c\u093f\u0930\u093e\u092e\u0940\u0915\u094b \u091c\u0928\u0938\u0902\u0916\u094d\u092f\u093e\u092e\u093e \u092d\u093f\u0928\u094d\u0928 \u0939\u0941\u0928\u094d\u091b \u0930 \u092c\u093f\u0930\u093e\u092e\u0940\u0915\u094b \u0909\u092e\u0947\u0930, \u091c\u093e\u0924\u093f, \u092d\u094c\u0917\u094b\u0932\u093f\u0915 \u0938\u094d\u0925\u093e\u0928 \u0930 \u0938\u0939\u0935\u0930\u094d\u0924\u0940 \u090f\u0932\u0930\u094d\u091c\u0940 \u0930\u094b\u0917\u0939\u0930\u0942 (\u091c\u0938\u094d\u0924\u0948 \u090f\u091f\u094b\u092a\u093f\u0915 \u0921\u0930\u094d\u092e\u0947\u091f\u093e\u0907\u091f\u093f\u0938) \u0938\u0901\u0917 \u0938\u092e\u094d\u092c\u0928\u094d\u0927\u093f\u0924 \u0939\u0941\u0928 \u0938\u0915\u094d\u091b\u0964<a id=\"xref-ref-4-9\" class=\"xref-bibr\" href=\"#ref-4\">\u096a<\/a> \u0917\u0932\u0924-\u0938\u0915\u093e\u0930\u093e\u0924\u094d\u092e\u0915 \u092a\u0930\u093f\u0923\u093e\u092e\u0939\u0930\u0942 sIgE \u092a\u0930\u0940\u0915\u094d\u0937\u0923\u0939\u0930\u0942\u092e\u093e \u0939\u0941\u0928 \u0938\u0915\u094d\u091b \u0915\u093f\u0928\u092d\u0928\u0947 \u092a\u0930\u0940\u0915\u094d\u0937\u0923\u092e\u093e \u0909\u091a\u094d\u091a \u0921\u093f\u0917\u094d\u0930\u0940 \u0917\u0948\u0930-\u0935\u093f\u0936\u093f\u0937\u094d\u091f \u092c\u093e\u0927\u094d\u092f\u0924\u093e \u0935\u093e \u0915\u0947\u0939\u0940 \u092c\u093f\u0930\u093e\u092e\u0940\u0939\u0930\u0942\u092e\u093e \u0909\u091a\u094d\u091a \u0915\u0941\u0932 IgE \u0938\u094d\u0924\u0930\u0939\u0930\u0942\u0964<a id=\"xref-ref-8-1\" class=\"xref-bibr\" href=\"#ref-8\">\u096e<\/a> \u0938\u093e\u0925\u0948, \u0935\u093f\u092d\u093f\u0928\u094d\u0928 \u092a\u094d\u0930\u092f\u094b\u0917\u0936\u093e\u0932\u093e\u0939\u0930\u0942\u092c\u093e\u091f sIgE \u0928\u0924\u093f\u091c\u093e\u0939\u0930\u0942 \u092a\u094d\u0930\u0924\u094d\u092f\u0915\u094d\u0937 \u0930\u0942\u092a\u092e\u093e \u0924\u0941\u0932\u0928\u093e \u0917\u0930\u094d\u0928 \u0938\u0915\u093f\u0901\u0926\u0948\u0928, \u0915\u093f\u0928\u0915\u093f \u090f\u0928\u094d\u091f\u093f\u091c\u0947\u0928\u0939\u0930\u0942\u0915\u094b \u0925\u094b\u0930\u0948 \u092b\u0930\u0915 \u0930\u0942\u092a\u0939\u0930\u0942 \u092a\u094d\u0930\u092f\u094b\u0917 \u0917\u0930\u094d\u0928 \u0938\u0915\u093f\u0928\u094d\u091b \u0930 \u091a\u0930 \u092a\u0930\u093f\u0923\u093e\u092e\u0939\u0930\u0942 \u0909\u0924\u094d\u092a\u093e\u0926\u0928 \u0917\u0930\u094d\u0928 \u0938\u0915\u093f\u0928\u094d\u091b\u0964<a id=\"xref-ref-1-2\" class=\"xref-bibr\" href=\"#ref-1\">\u0967<\/a>\n<\/p>\n<\/div>\n<div class=\"section\" id=\"sec-6\">\n<h2 class=\"\">OFC \u0938\u0902\u0917 \u092a\u0941\u0937\u094d\u091f\u093f\u0915\u0930\u0923 \u092a\u0930\u0940\u0915\u094d\u0937\u0923<\/h2>\n<p id=\"p-14\">\u092f\u0926\u093f \u092c\u093f\u0930\u093e\u092e\u0940\u0915\u094b \u0907\u0924\u093f\u0939\u093e\u0938 SPT \u0935\u093e sIgE \u0928\u0924\u093f\u091c\u093e\u0938\u0901\u0917 \u092c\u0947\u092e\u0947\u0932 \u091b \u092d\u0928\u0947, OFC \u0932\u0947 \u090f\u0932\u0930\u094d\u091c\u0940\u0932\u093e\u0908 \u092a\u0941\u0937\u094d\u091f\u093f \u0917\u0930\u094d\u0928 \u0935\u093e \u0928\u093f\u0936\u094d\u091a\u093f\u0924 \u0930\u0942\u092a\u092e\u093e \u0936\u093e\u0938\u0928 \u0917\u0930\u094d\u0928 \u0938\u0915\u094d\u091b\u0964<a id=\"xref-ref-7-1\" class=\"xref-bibr\" href=\"#ref-7\">\u096d<\/a> \u092f\u0938 \u092a\u094d\u0930\u0915\u094d\u0930\u093f\u092f\u093e\u0915\u094b \u0915\u094d\u0930\u092e\u092e\u093e, \u092c\u093f\u0930\u093e\u092e\u0940\u0939\u0930\u0942\u0932\u093e\u0908 \u092c\u0922\u094d\u0926\u094b \u0916\u0941\u0930\u093e\u0915\u0939\u0930\u0942 \u0926\u093f\u0907\u0928\u094d\u091b &#8211; \u0935\u093e \u092f\u0926\u093f \u091c\u094b\u0916\u093f\u092e \u0915\u092e \u092e\u093e\u0928\u093f\u0928\u094d\u091b \u092d\u0928\u0947 \u090f\u0915 \u090f\u0915\u0932 \u0916\u0941\u0930\u093e\u0915 &#8211; \u092a\u094d\u0930\u0936\u094d\u0928\u092e\u093e \u0930\u0939\u0947\u0915\u094b \u0916\u093e\u0928\u093e\u0915\u094b \u0930 \u092a\u094d\u0930\u0924\u093f\u0915\u094d\u0930\u093f\u092f\u093e\u0939\u0930\u0942\u0915\u094b \u0932\u093e\u0917\u093f HCP \u0915\u094b \u092a\u094d\u0930\u0924\u094d\u092f\u0915\u094d\u0937 \u0928\u093f\u0930\u0940\u0915\u094d\u0937\u0923\u092e\u093e \u0928\u093f\u0917\u0930\u093e\u0928\u0940 \u0917\u0930\u093f\u0928\u094d\u091b\u0964<a id=\"xref-ref-4-10\" class=\"xref-bibr\" href=\"#ref-4\">\u096a \u0967\u0967<\/a> \u092f\u0926\u094d\u092f\u092a\u093f OFC \u0932\u093e\u0908 IgE-\u092e\u0927\u094d\u092f\u0938\u094d\u0925\u0924\u093e \u092b\u0942\u0921 \u090f\u0932\u0930\u094d\u091c\u0940 \u092a\u0941\u0937\u094d\u091f\u093f \u0917\u0930\u094d\u0928\u0915\u094b \u0932\u093e\u0917\u093f \u0938\u0941\u0928\u0915\u094b \u092e\u093e\u0928\u0915 \u092e\u093e\u0928\u093f\u0928\u094d\u091b, \u092f\u0926\u093f \u092c\u093f\u0930\u093e\u092e\u0940\u0938\u0901\u0917 \u0915\u094d\u0932\u093f\u0928\u093f\u0915\u0932 \u092a\u094d\u0930\u0924\u093f\u0915\u094d\u0930\u093f\u092f\u093e\u0915\u094b \u0938\u094d\u092a\u0937\u094d\u091f \u0930 \u0935\u093f\u0936\u094d\u0935\u0938\u094d\u0924 \u091a\u093f\u0915\u093f\u0924\u094d\u0938\u093e \u0907\u0924\u093f\u0939\u093e\u0938 \u0930 \u091c\u094d\u091e\u093e\u0924 \u090f\u0932\u0930\u094d\u091c\u0940\u0915\u094b \u0932\u093e\u0917\u093f \u0938\u0915\u093e\u0930\u093e\u0924\u094d\u092e\u0915 SPT \u0935\u093e sIgE \u092a\u0930\u0940\u0915\u094d\u0937\u0923\u0939\u0930\u0942 \u091b\u0928\u094d \u092d\u0928\u0947 \u092f\u094b \u0905\u0928\u093f\u0935\u093e\u0930\u094d\u092f \u091b\u0948\u0928\u0964<a id=\"xref-ref-4-11\" class=\"xref-bibr\" href=\"#ref-4\">\u096a<\/a> \u092f\u0926\u093f OFC \u0915\u094b \u0938\u092e\u092f\u092e\u093e \u0915\u0941\u0928\u0948 \u0932\u0915\u094d\u0937\u0923\u0939\u0930\u0942 \u0926\u0947\u0916\u093e \u092a\u0930\u094d\u0926\u0948\u0928\u0928\u094d \u092d\u0928\u0947, \u090f\u0932\u0930\u094d\u091c\u0947\u0928\u093f\u0915 \u0916\u093e\u0928\u093e\u0915\u094b \u0909\u092e\u0947\u0930-\u0909\u092a\u092f\u0941\u0915\u094d\u0924 \u092d\u093e\u0917 \u0916\u093e\u090f\u0915\u094b \u0938\u0941\u0928\u093f\u0936\u094d\u091a\u093f\u0924 \u0917\u0930\u093f\u0938\u0915\u0947\u092a\u091b\u093f, IgE-\u092e\u0927\u094d\u092f\u0938\u094d\u0925\u0924\u093e \u092b\u0942\u0921 \u090f\u0932\u0930\u094d\u091c\u0940\u0932\u093e\u0908 \u090f\u0932\u0930\u094d\u091c\u0940\u0915\u094b \u0932\u093e\u0917\u093f \u0905\u0938\u094d\u0935\u0940\u0915\u093e\u0930 \u0917\u0930\u094d\u0928 \u0938\u0915\u093f\u0928\u094d\u091b\u0964<a id=\"xref-ref-12-1\" class=\"xref-bibr\" href=\"#ref-12\">\u0967\u0968<\/a> \u0938\u0939\u093f\u0937\u094d\u0923\u0941\u0924\u093e \u0930 \u0906\u0924\u094d\u092e\u0935\u093f\u0936\u094d\u0935\u093e\u0938 \u0938\u0941\u0928\u093f\u0936\u094d\u091a\u093f\u0924 \u0917\u0930\u094d\u0928 \u090f\u0932\u0930\u094d\u091c\u0940 \u092c\u093e\u0930\u092e\u094d\u092c\u093e\u0930 \u0916\u093e\u0928\u0941 \u0906\u0935\u0936\u094d\u092f\u0915 \u091b \u0915\u093f \u092f\u094b \u090f\u0915 \u0905\u0938\u0941\u0930\u0915\u094d\u0937\u093f\u0924 \u0938\u0947\u091f\u093f\u0919 \u092e\u093e \u0916\u093e\u0928 \u0938\u0915\u093f\u0928\u094d\u091b\u0964<a id=\"xref-ref-12-2\" class=\"xref-bibr\" href=\"#ref-12\">\u0967\u0968<\/a> \u092f\u0926\u093f \u0938\u094d\u092a\u0937\u094d\u091f, \u0924\u0924\u094d\u0915\u093e\u0932-\u0938\u0941\u0930\u0941\u0935\u093e\u0924 \u0932\u0915\u094d\u0937\u0923\u0939\u0930\u0942 \u0935\u093f\u0915\u093e\u0938 \u092d\u090f\u092e\u093e, \u0916\u093e\u0928\u093e \u090f\u0932\u0930\u094d\u091c\u0940 \u0928\u093f\u0926\u093e\u0928 \u092a\u0941\u0937\u094d\u091f\u093f \u0917\u0930\u094d\u0928 \u0938\u0915\u093f\u0928\u094d\u091b \u0930 \u0916\u093e\u0928\u093e\u092c\u093e\u091f \u091c\u094b\u0917\u093f\u0928\u0948 \u092a\u0930\u094d\u091b\u0964<a id=\"xref-ref-4-12\" class=\"xref-bibr\" href=\"#ref-4\">\u096a<\/a> \u0916\u093e\u0928\u093e\u0915\u094b \u090f\u0932\u0930\u094d\u091c\u0940 \u092c\u0922\u094d\u0926\u0948 \u0917\u090f\u0915\u094b \u0939\u0941\u0928\u093e\u0932\u0947, \u092e\u094c\u0916\u093f\u0915 \u0938\u0939\u093f\u0937\u094d\u0923\u0941\u0924\u093e\u0915\u094b \u0935\u093f\u0915\u093e\u0938\u0915\u094b \u092e\u0942\u0932\u094d\u092f\u093e\u0919\u094d\u0915\u0928 \u0917\u0930\u094d\u0928 \u0928\u093f\u092f\u092e\u093f\u0924 \u0930\u0942\u092a\u092e\u093e OFC \u0917\u0930\u094d\u0928 \u0938\u0915\u093f\u0928\u094d\u091b\u0964<a id=\"xref-ref-4-13\" class=\"xref-bibr\" href=\"#ref-4\">\u096a<\/a>\n<\/p>\n<\/div>\n<div class=\"section\" id=\"sec-7\">\n<h2 class=\"\">\u092a\u0930\u0940\u0915\u094d\u0937\u0923\u0939\u0930\u0942 \u091c\u0941\u0928 \u0938\u093f\u092b\u093e\u0930\u093f\u0938 \u0917\u0930\u093f\u090f\u0915\u094b \u091b\u0948\u0928<\/h2>\n<p id=\"p-15\">\u092e\u093e \u0938\u0902\u0915\u094d\u0937\u0947\u092a \u0917\u0930\u0947 \u0905\u0928\u0941\u0938\u093e\u0930 <a id=\"xref-boxed-text-1-1\" class=\"xref-boxed-text\" href=\"#boxed-text-1\">\u092c\u0915\u094d\u0938 1<\/a>\u0905\u0924\u093f\u0930\u093f\u0915\u094d\u0924 \u092a\u0930\u0940\u0915\u094d\u0937\u0923 \u092a\u094d\u0930\u0935\u093f\u0927\u093f\u0939\u0930\u0942 \u0909\u092a\u0932\u092c\u094d\u0927 \u091b\u0928\u094d; \u092f\u0926\u094d\u092f\u092a\u093f, \u092f\u0940 \u0935\u094d\u092f\u093e\u092a\u0915 \u0930\u0942\u092a\u092e\u093e \u0938\u093f\u092b\u093e\u0930\u093f\u0938 \u0917\u0930\u093f\u0901\u0926\u0948\u0928, \u0915\u093f\u0928\u0915\u093f \u0924\u093f\u0928\u0940\u0939\u0930\u0942\u0938\u0901\u0917 \u0935\u093f\u0936\u093f\u0937\u094d\u091f \u090f\u0932\u0930\u094d\u091c\u0940 \u091c\u093e\u0928\u0915\u093e\u0930\u0940\u0915\u094b \u0915\u092e\u0940 \u091b, \u0905\u0928\u093e\u0935\u0936\u094d\u092f\u0915 \u091c\u094b\u0916\u093f\u092e\u0939\u0930\u0942 \u091b\u0928\u094d \u0935\u093e \u0915\u094d\u0932\u093f\u0928\u093f\u0915\u0932 \u092a\u094d\u0930\u092f\u094b\u0917\u0915\u094b \u0932\u093e\u0917\u093f \u0925\u092a \u0905\u0928\u0941\u0938\u0928\u094d\u0927\u093e\u0928 \u0906\u0935\u0936\u094d\u092f\u0915 \u091b\u0964<a id=\"xref-ref-4-14\" class=\"xref-bibr\" href=\"#ref-4\">\u096a \u0967\u0969<\/a> \u092f\u0938\u092c\u093e\u0939\u0947\u0915, \u0920\u0942\u0932\u093e \u092a\u094d\u092f\u093e\u0928\u0932 \u0938\u094d\u0915\u094d\u0930\u093f\u0928\u0939\u0930\u0942 \u0938\u093f\u092b\u093e\u0930\u093f\u0938 \u0917\u0930\u093f\u0901\u0926\u0948\u0928, \u0915\u093f\u0928\u0915\u093f \u0924\u093f\u0928\u0940\u0939\u0930\u0942\u0932\u0947 \u0917\u0932\u0924-\u0938\u0915\u093e\u0930\u093e\u0924\u094d\u092e\u0915 \u0928\u0924\u093f\u091c\u093e\u0939\u0930\u0942, \u0905\u0928\u093e\u0935\u0936\u094d\u092f\u0915 \u0916\u093e\u0928\u093e \u092a\u094d\u0930\u0924\u093f\u092c\u0928\u094d\u0927\u0939\u0930\u0942 \u0930 \u0925\u092a \u092b\u0932\u094b-\u0905\u092a \u092a\u0930\u0940\u0915\u094d\u0937\u0923\u0939\u0930\u0942\u0915\u094b \u091c\u094b\u0916\u093f\u092e \u092c\u0922\u093e\u0909\u0901\u091b\u0928\u094d\u0964<a id=\"xref-ref-4-15\" class=\"xref-bibr\" href=\"#ref-4\">\u096a<\/a> Ara h2 \u0915\u092e\u094d\u092a\u094b\u0928\u0947\u0928\u094d\u091f\u0915\u094b \u0932\u093e\u0917\u093f \u0915\u092e\u094d\u092a\u094b\u0928\u0947\u0928\u094d\u091f-\u0938\u092e\u093e\u0927\u093e\u0928 \u0928\u093f\u0926\u093e\u0928 \u092a\u0930\u0940\u0915\u094d\u0937\u0923 \u092e\u0942\u0902\u0917\u092b\u0932\u0940 \u090f\u0932\u0930\u094d\u091c\u0940\u0915\u094b \u0932\u093e\u0917\u093f \u0938\u093f\u092b\u093e\u0930\u093f\u0938 \u0917\u0930\u093f\u090f\u0915\u094b \u091b\u0964<a id=\"xref-ref-14-1\" class=\"xref-bibr\" href=\"#ref-14\">\u0967\u096a<\/a>; \u092f\u0926\u094d\u092f\u092a\u093f, \u0905\u092e\u0947\u0930\u093f\u0915\u0940 \u0926\u093f\u0936\u093e\u0928\u093f\u0930\u094d\u0926\u0947\u0936\u0939\u0930\u0942\u0932\u0947 \u0905\u0928\u094d\u092f \u0916\u093e\u0926\u094d\u092f \u092a\u0926\u093e\u0930\u094d\u0925\u0939\u0930\u0942\u0915\u094b \u0932\u093e\u0917\u093f \u0915\u092e\u094d\u092a\u094b\u0928\u0947\u0928\u094d\u091f \u092a\u0930\u0940\u0915\u094d\u0937\u0923 \u0938\u093f\u092b\u093e\u0930\u093f\u0938 \u0917\u0930\u094d\u0926\u0948\u0928\u0928\u094d, \u0930 \u092f\u0941\u0930\u094b\u092a\u0947\u0932\u0940 \u0926\u093f\u0936\u093e\u0928\u093f\u0930\u094d\u0926\u0947\u0936\u0939\u0930\u0942\u0932\u0947 \u0905\u0924\u093f\u0930\u093f\u0915\u094d\u0924 \u091c\u093e\u0928\u0915\u093e\u0930\u0940 \u0906\u0935\u0936\u094d\u092f\u0915 \u092d\u090f\u092e\u093e SPT \u0935\u093e sIgE \u092a\u0930\u093f\u0923\u093e\u092e\u0939\u0930\u0942 \u092c\u093e\u0939\u0947\u0915 \u0915\u092e\u094d\u092a\u094b\u0928\u0947\u0928\u094d\u091f \u092a\u0930\u0940\u0915\u094d\u0937\u0923 \u092e\u093e\u0924\u094d\u0930 \u0938\u093f\u092b\u093e\u0930\u093f\u0938 \u0917\u0930\u094d\u091b\u0928\u094d\u0964<a id=\"xref-ref-4-16\" class=\"xref-bibr\" href=\"#ref-4\">\u096a \u096d<\/a>\n<\/p>\n<div class=\"boxed-text\" id=\"boxed-text-1\"><span class=\"boxed-text-label\">\u092c\u0915\u094d\u0938 \u0967<\/span> <\/p>\n<h3>\u092a\u0930\u0940\u0915\u094d\u0937\u0923 \u0935\u093f\u0927\u093f\u0939\u0930\u0942 \u0939\u0941\u0928\u094d <em>\u0939\u094b\u0907\u0928<\/em> IgE-\u092e\u0927\u094d\u092f\u0938\u094d\u0925\u0924\u093e \u0916\u093e\u0928\u093e \u090f\u0932\u0930\u094d\u091c\u0940 \u0928\u093f\u0926\u093e\u0928\u0915\u094b \u0932\u093e\u0917\u093f \u0938\u093f\u092b\u093e\u0930\u093f\u0938 \u0917\u0930\u093f\u090f\u0915\u094b<a id=\"xref-ref-4-17\" class=\"xref-bibr\" href=\"#ref-4\">\u096a \u0967\u0969<\/a><\/h3>\n<div id=\"sec-8\" class=\"subsection\">\n<h4>\u092a\u094d\u0930\u0923\u093e\u0932\u0940\u0917\u0924 \u092a\u094d\u0930\u0924\u093f\u0915\u094d\u0930\u093f\u092f\u093e\u0939\u0930\u0942\u0915\u094b \u092c\u0922\u094d\u0926\u094b \u091c\u094b\u0916\u093f\u092e<\/h4>\n<\/div>\n<div id=\"sec-10\" class=\"subsection\">\n<h4>\u092a\u094d\u0930\u0924\u093f\u0915\u094d\u0930\u093f\u092f\u093e\u0939\u0930\u0942 \u090f\u0932\u0930\u094d\u091c\u0940\u0915\u094b \u0938\u091f\u094d\u091f\u093e \u0938\u093e\u092e\u093e\u0928\u094d\u092f \u0907\u092e\u094d\u092f\u0941\u0928\u094b\u0932\u094b\u091c\u093f\u0915\u0932 \u092e\u0947\u092e\u094b\u0930\u0940\u0915\u094b \u0915\u093e\u0930\u0923 \u0939\u094b<\/h4>\n<p id=\"p-27\">ALCAT, \u090f\u0928\u094d\u091f\u093f\u091c\u0928 \u0932\u094d\u092f\u0942\u0915\u094b\u0938\u093e\u0907\u091f \u090f\u0928\u094d\u091f\u093f\u092c\u0921\u0940 \u092a\u0930\u0940\u0915\u094d\u0937\u0923; IgE, \u0907\u092e\u094d\u092f\u0941\u0928\u094b\u0917\u094d\u0932\u094b\u092c\u0941\u0932\u093f\u0928 \u0908; \u0906\u0908\u091c\u0940\u091c\u0940, \u0907\u092e\u094d\u092f\u0941\u0928\u094b\u0917\u094d\u0932\u094b\u092c\u0941\u0932\u093f\u0928 \u091c\u0940\u0964<\/p>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"section\" id=\"sec-11\">\n<h2 class=\"\">IgE-\u092e\u0927\u094d\u092f\u0938\u094d\u0925\u0924\u093e \u0916\u093e\u0928\u093e \u090f\u0932\u0930\u094d\u091c\u0940 \u0928\u093f\u0926\u093e\u0928 \u0915\u094b \u092a\u0930\u093f\u0923\u093e\u092e \u0915\u094b \u0935\u094d\u092f\u093e\u0916\u094d\u092f\u093e<\/h2>\n<p id=\"p-28\">IgE-\u092e\u0927\u094d\u092f\u0938\u094d\u0925\u0924\u093e\u092f\u0941\u0915\u094d\u0924 \u0916\u093e\u0928\u093e\u0915\u094b \u090f\u0932\u0930\u094d\u091c\u0940 \u0930 \u0916\u093e\u0928\u093e\u092e\u093e \u0938\u0902\u0935\u0947\u0926\u0928\u0936\u0940\u0932\u0924\u093e \u092c\u0940\u091a\u0915\u094b \u092d\u093f\u0928\u094d\u0928\u0924\u093e \u092c\u0941\u091d\u094d\u0928\u0947 \u0930 \u0938\u091e\u094d\u091a\u093e\u0930 \u0917\u0930\u094d\u0928\u0941 \u0938\u0939\u0940 \u0909\u092a\u091a\u093e\u0930\u0915\u094b \u0932\u093e\u0917\u093f \u092e\u0939\u0924\u094d\u0924\u094d\u0935\u092a\u0942\u0930\u094d\u0923 \u091b, \u0915\u093f\u0928\u0915\u093f \u0918\u094b\u0937\u093f\u0924 \u090f\u0932\u0930\u094d\u091c\u0940\u0939\u0930\u0942\u0915\u094b 50-90% \u0935\u093e\u0938\u094d\u0924\u0935\u093f\u0915 \u090f\u0932\u0930\u094d\u091c\u0940\u0939\u0930\u0942 \u0939\u094b\u0907\u0928\u0928\u094d\u0964<a id=\"xref-ref-2-10\" class=\"xref-bibr\" href=\"#ref-2\">\u0968 \u096f<\/a> \u0905\u0927\u094d\u092f\u092f\u0928\u0939\u0930\u0942\u0932\u0947 \u0915\u0947\u0939\u0940 \u090f\u0928\u094d\u091f\u093f\u091c\u0947\u0928\u094d\u0938\u0915\u093e \u0932\u093e\u0917\u093f OFCs \u0915\u094b \u0906\u0935\u0936\u094d\u092f\u0915\u0924\u093e \u0915\u092e \u0917\u0930\u094d\u0928 \u0915\u091f-\u0905\u092b \u0928\u093f\u0930\u094d\u0923\u092f \u092c\u093f\u0928\u094d\u0926\u0941\u0915\u094b \u0930\u0942\u092a\u092e\u093e \u092a\u094d\u0930\u092f\u094b\u0917 \u0917\u0930\u094d\u0928 \u090f\u0932\u0930\u094d\u091c\u0940 \u092a\u094d\u0930\u0924\u093f\u0915\u094d\u0930\u093f\u092f\u093e\u0915\u094b \u0932\u093e\u0917\u093f 95% \u0915\u094b PPV \u0938\u0901\u0917 sIgE \u092e\u093e\u0928\u0939\u0930\u0942 \u092a\u0939\u093f\u091a\u093e\u0928 \u0917\u0930\u0947\u0915\u094b \u091b,<a id=\"xref-ref-15-1\" class=\"xref-bibr\" href=\"#ref-15\">\u0967\u096b<\/a> \u0915\u091f-\u0905\u092b \u0928\u093f\u0930\u094d\u0923\u092f \u092c\u093f\u0928\u094d\u0926\u0941\u0939\u0930\u0942 \u0935\u093f\u0936\u093f\u0937\u094d\u091f \u091c\u0928\u0938\u0902\u0916\u094d\u092f\u093e\u092c\u093e\u091f \u0935\u094d\u092f\u0941\u0924\u094d\u092a\u0928\u094d\u0928 \u0939\u0941\u0928\u094d\u091b\u0928\u094d \u0930 \u0915\u094d\u0932\u093f\u0928\u093f\u0915\u0932 \u0909\u092a\u092f\u094b\u0917\u093f\u0924\u093e \u0938\u0940\u092e\u093f\u0924 \u0917\u0930\u094d\u0926\u0948 \u092a\u094d\u0930\u0924\u094d\u092f\u0947\u0915 \u091c\u0928\u0938\u0902\u0916\u094d\u092f\u093e\u0915\u094b \u0932\u093e\u0917\u093f \u092a\u094d\u0930\u092e\u093e\u0923\u0940\u0915\u0930\u0923 \u091a\u093e\u0939\u093f\u0928\u094d\u091b\u0964<a id=\"xref-ref-6-1\" class=\"xref-bibr\" href=\"#ref-6\">\u096c<\/a> \u092a\u0939\u093f\u0932\u0947 \u092a\u0930\u093f\u092d\u093e\u0937\u093f\u0924 \u0915\u091f-\u0905\u092b \u092c\u093f\u0928\u094d\u0926\u0941\u0939\u0930\u0942 \u092a\u094d\u0930\u092f\u094b\u0917 \u0917\u0930\u094d\u0928\u0941\u0915\u094b \u0938\u091f\u094d\u091f\u093e, \u092c\u093f\u0930\u093e\u092e\u0940\u0915\u094b \u0907\u0924\u093f\u0939\u093e\u0938 \u0930 \u0928\u093f\u0926\u093e\u0928\u093e\u0924\u094d\u092e\u0915 \u092a\u0930\u0940\u0915\u094d\u0937\u0923\u0926\u094d\u0935\u093e\u0930\u093e \u092a\u094d\u0930\u0926\u093e\u0928 \u0917\u0930\u093f\u090f\u0915\u094b \u0938\u092e\u094d\u092d\u093e\u0935\u0928\u093e \u0905\u0928\u0941\u092a\u093e\u0924\u092e\u093e \u0906\u0927\u093e\u0930\u093f\u0924 \u092a\u0942\u0930\u094d\u0935-\u092a\u0930\u0940\u0915\u094d\u0937\u0923 \u0938\u092e\u094d\u092d\u093e\u0935\u094d\u092f\u0924\u093e \u0935\u093f\u0915\u093e\u0938 \u0917\u0930\u094d\u0928 \u0938\u0901\u0917\u0948 \u092a\u094d\u0930\u092f\u094b\u0917 \u0917\u0930\u093f\u0928\u0941\u092a\u0930\u094d\u091b\u0964 \u0938\u092e\u094d\u092d\u093e\u0935\u094d\u092f\u0924\u093e \u0930 \u0938\u092e\u094d\u092d\u093e\u0935\u094d\u092f\u0924\u093e \u0905\u0928\u0941\u092a\u093e\u0924\u0939\u0930\u0942 \u092a\u094d\u0930\u092f\u094b\u0917 \u0917\u0930\u094d\u0926\u093e, \u0915\u094d\u0932\u093f\u0928\u093f\u0915\u0932 \u0907\u0924\u093f\u0939\u093e\u0938 \u0935\u093f\u0936\u093f\u0937\u094d\u091f \u092a\u0941\u0937\u094d\u091f\u093f \u092a\u0930\u0940\u0915\u094d\u0937\u0923 \u092a\u0930\u093f\u0923\u093e\u092e\u0939\u0930\u0942 \u091c\u0924\u094d\u0924\u093f\u0915\u0948 \u091c\u093e\u0928\u0915\u093e\u0930\u0940\u092e\u0942\u0932\u0915 \u0939\u0941\u0928\u094d\u091b, \u0915\u093f\u0928\u092d\u0928\u0947 \u092a\u094b\u0938\u094d\u091f-\u092a\u0930\u0940\u0915\u094d\u0937\u0923 \u0938\u092e\u094d\u092d\u093e\u0935\u0928\u093e\u0939\u0930\u0942\u0932\u0947 \u0928\u0948\u0926\u093e\u0928\u093f\u0915 \u200b\u200b\u200b\u200b\u0907\u0924\u093f\u0939\u093e\u0938\u0915\u093e \u0938\u093e\u0925\u0948 \u0928\u093f\u0926\u093e\u0928 \u092a\u0930\u093f\u0923\u093e\u092e\u0939\u0930\u0942 \u092a\u0928\u093f \u0938\u092e\u093e\u0935\u0947\u0936 \u0917\u0930\u094d\u0926\u091b\u0964<a id=\"xref-ref-16-1\" class=\"xref-bibr\" href=\"#ref-16\">\u0967\u096c<\/a> \u091a\u093f\u0915\u093f\u0924\u094d\u0938\u093e \u0907\u0924\u093f\u0939\u093e\u0938, SPTs \u0930\/\u0935\u093e OFCs \u0905\u091d\u0948 \u092a\u0928\u093f \u091c\u093e\u0928\u0915\u093e\u0930\u0940\u092e\u0942\u0932\u0915 \u091b\u0928\u094d, \u0915\u093f\u0928\u0915\u093f \u0909\u091a\u094d\u091a \u0915\u0941\u0932 sIgE \u0938\u094d\u0924\u0930 \u092d\u090f\u0915\u093e \u092c\u093f\u0930\u093e\u092e\u0940\u0939\u0930\u0942 \u091c\u0941\u0928 95% PPV \u092d\u0928\u094d\u0926\u093e \u0915\u092e \u091b\u0928\u094d \u0905\u091d\u0948 \u092a\u0928\u093f \u090f\u0932\u0930\u094d\u091c\u0940 \u092a\u094d\u0930\u0924\u093f\u0915\u094d\u0930\u093f\u092f\u093e\u0939\u0930\u0942\u0915\u094b \u091c\u094b\u0916\u093f\u092e\u092e\u093e \u0939\u0941\u0928 \u0938\u0915\u094d\u091b\u0964 \u0925\u092a \u0930\u0942\u092a\u092e\u093e, \u0905\u0923\u094d\u0921\u093e \u0930 \u092c\u0926\u093e\u092e \u091c\u0938\u094d\u0924\u093e \u0935\u093f\u0936\u093f\u0937\u094d\u091f \u090f\u0932\u0930\u094d\u091c\u0940\u0939\u0930\u0942 \u092c\u0940\u091a\u0915\u094b \u0938\u092e\u094d\u092c\u0928\u094d\u0927 \u092a\u0939\u093f\u091a\u093e\u0928 \u0917\u0930\u093f\u090f\u0915\u094b \u091b \u091c\u0938\u0932\u093e\u0908 \u092a\u0930\u0940\u0915\u094d\u0937\u0923 \u092e\u093e\u0930\u094d\u092b\u0924 \u092a\u0941\u0937\u094d\u091f\u093f \u0917\u0930\u094d\u0928 \u0906\u0935\u0936\u094d\u092f\u0915 \u091b\u0964<a id=\"xref-ref-17-1\" class=\"xref-bibr\" href=\"#ref-17\">\u0967\u096d<\/a>\n<\/p>\n<\/div>\n<div class=\"section\" id=\"sec-12\">\n<h2 class=\"\">overtesting \u0915\u094b \u092a\u094d\u0930\u092d\u093e\u0935<\/h2>\n<p id=\"p-29\">\u0918\u0930\u0947\u0932\u0941 \u0928\u093f\u0926\u093e\u0928\u0915\u094b \u0905\u0924\u094d\u092f\u0927\u093f\u0915 \u092a\u0930\u0940\u0915\u094d\u0937\u0923 \u0930 \u0926\u0941\u0930\u0941\u092a\u092f\u094b\u0917\u0932\u0947 IgE-\u092e\u0927\u094d\u092f\u0938\u094d\u0925\u0924\u093e \u0916\u093e\u0928\u093e \u090f\u0932\u0930\u094d\u091c\u0940\u0915\u094b \u0913\u092d\u0930 \u0921\u093e\u092f\u0917\u094d\u0928\u094b\u0938\u093f\u0938\u092e\u093e \u092a\u0930\u093f\u0923\u093e\u092e \u0926\u093f\u0928\u094d\u091b, \u091c\u0938\u0932\u0947 \u092c\u093f\u0930\u093e\u092e\u0940 \u0930 \u0939\u0947\u0930\u091a\u093e\u0939\u0915\u0930\u094d\u0924\u093e\u0939\u0930\u0942\u0915\u094b \u0932\u093e\u0917\u093f \u0905\u0928\u093e\u0935\u0936\u094d\u092f\u0915 \u092e\u0928\u094b\u0938\u093e\u092e\u093e\u091c\u093f\u0915 \u0930 \u0906\u0930\u094d\u0925\u093f\u0915 \u092c\u094b\u091d \u0928\u093f\u092e\u094d\u0924\u094d\u092f\u093e\u0909\u0901\u091b, \u091c\u0938\u092e\u093e \u0916\u093e\u0928\u093e \u092c\u0947\u0935\u093e\u0938\u094d\u0924\u093e, \u092a\u094b\u0937\u0923 \u0938\u0928\u094d\u0924\u0941\u0932\u093f\u0924 \u0906\u0939\u093e\u0930 \u0915\u093e\u092f\u092e \u0930\u093e\u0916\u094d\u0928 \u0915\u0920\u093f\u0928\u093e\u0908 \u0930 \u0925\u092a \u0906\u0930\u094d\u0925\u093f\u0915 \u092c\u094b\u091d (\u092a\u094d\u0930\u0924\u094d\u092f\u0915\u094d\u0937 \u0930 \u0905\u092a\u094d\u0930\u0924\u094d\u092f\u0915\u094d\u0937 \u0926\u0941\u0935\u0948)\u0964 \u0938\u0941\u0930\u0915\u094d\u0937\u093f\u0924 \u0916\u093e\u0928\u093e \u0930 \u091a\u093f\u0915\u093f\u0924\u094d\u0938\u093e \u0916\u0930\u094d\u091a\u0915\u094b \u0932\u093e\u0917\u093f\u0964<a id=\"xref-ref-18-1\" class=\"xref-bibr\" href=\"#ref-18\">18-20<\/a>\n<\/p>\n<\/div>\n<div class=\"section\" id=\"sec-13\">\n<h2 class=\"\">\u092c\u0926\u093e\u092e \u090f\u0932\u0930\u094d\u091c\u0940 \u092d\u090f\u0915\u094b \u092d\u0930\u094d\u0916\u0930\u0948 \u0928\u093f\u0926\u093e\u0928 \u0917\u0930\u093f\u090f\u0915\u094b \u092c\u093f\u0930\u093e\u092e\u0940\u0915\u094b \u092d\u093e\u0907\u092c\u0939\u093f\u0928\u0940\u092e\u093e \u092e\u0948\u0932\u0947 \u092e\u0942\u0932\u094d\u092f\u093e\u0919\u094d\u0915\u0928 \u0915\u0938\u0930\u0940 \u0917\u0930\u094d\u0928\u0947?<\/h2>\n<p id=\"p-30\">\u090f\u0909\u091f\u093e \u0968 \u0935\u0930\u094d\u0937\u0915\u094b \u0915\u0947\u091f\u093e\u0932\u0947 \u090f\u0932\u0930\u094d\u091c\u0940\u0915\u094b \u0915\u0941\u0928\u0948 \u0907\u0924\u093f\u0939\u093e\u0938 \u0928\u092d\u090f\u0915\u094b \u0924\u0930 \u0939\u093e\u0932\u0938\u093e\u0932\u0948 \u092c\u0926\u093e\u092e\u0915\u094b \u090f\u0932\u0930\u094d\u091c\u0940 \u092d\u090f\u0915\u094b \u0928\u093f\u0926\u093e\u0928 \u0917\u0930\u0947\u0915\u094b \u0920\u0942\u0932\u093e \u092d\u093e\u0907\u0938\u0901\u0917 \u092a\u094d\u0930\u0938\u094d\u0924\u0941\u0924 \u0917\u0930\u0947\u0915\u094b \u091b\u0964 \u092a\u0930\u0940\u0915\u094d\u0937\u0923 \u092a\u094d\u0930\u0938\u094d\u0924\u093e\u0935 \u0917\u0930\u094d\u0928\u0941\u092a\u0930\u094d\u091b? \u092c\u0926\u093e\u092e \u090f\u0932\u0930\u094d\u091c\u0940 \u092d\u090f\u0915\u093e \u092c\u093f\u0930\u093e\u092e\u0940\u0915\u094b \u0926\u093e\u091c\u0941\u092d\u093e\u0907\u0932\u093e\u0908 \u092c\u0926\u093e\u092e\u0915\u094b \u090f\u0932\u0930\u094d\u091c\u0940 \u0939\u0941\u0928\u0947 \u092a\u094d\u0930\u093f\u091f\u0947\u0938\u094d\u091f \u0938\u092e\u094d\u092d\u093e\u0935\u094d\u092f\u0924\u093e \u0909\u092a\u0932\u092c\u094d\u0927 \u0921\u093e\u091f\u093e\u0915\u094b \u0906\u0927\u093e\u0930\u092e\u093e 5% \u0928\u093f\u0930\u094d\u0927\u093e\u0930\u0923 \u0917\u0930\u093f\u090f\u0915\u094b \u0925\u093f\u092f\u094b\u0964 \u092f\u0926\u093f \u092a\u0930\u0940\u0915\u094d\u0937\u0923\u0915\u094b \u0906\u0926\u0947\u0936 \u0926\u093f\u0907\u092f\u094b \u092d\u0928\u0947, Ara h2 \u0932\u0947 \u0915\u094d\u0930\u092e\u0936\u0903 5.5 \u0930 0.17 \u0915\u094b \u0909\u091a\u094d\u091a\u0924\u092e \u0935\u093f\u0936\u093f\u0937\u094d\u091f\u0924\u093e \u0930 \u0938\u0915\u093e\u0930\u093e\u0924\u094d\u092e\u0915 \u0930 \u0928\u0915\u093e\u0930\u093e\u0924\u094d\u092e\u0915 \u0938\u092e\u094d\u092d\u093e\u0935\u0928\u093e \u0905\u0928\u0941\u092a\u093e\u0924 \u092a\u094d\u0930\u0926\u093e\u0928 \u0917\u0930\u094d\u0928\u0947\u091b\u0964 \u092a\u0942\u0930\u094d\u0935 \u092a\u0930\u0940\u0915\u094d\u0937\u0923 \u0938\u092e\u094d\u092d\u093e\u0935\u094d\u092f\u0924\u093e, \u092a\u0942\u0930\u094d\u0935 \u092a\u0930\u0940\u0915\u094d\u0937\u0923 \u092c\u093e\u0927\u093e \u0930 \u0938\u092e\u094d\u092d\u093e\u0935\u0928\u093e \u0905\u0928\u0941\u092a\u093e\u0924\u0915\u094b \u0906\u0927\u093e\u0930\u092e\u093e, \u092a\u094b\u0938\u094d\u091f-\u092a\u0930\u0940\u0915\u094d\u0937\u0923 \u0938\u092e\u094d\u092d\u093e\u0935\u094d\u092f\u0924\u093e 0.8% \u0930 25% \u0915\u094b \u092c\u0940\u091a\u092e\u093e \u0925\u093f\u092f\u094b (<a id=\"xref-fig-1-1\" class=\"xref-fig\" href=\"#F1\">\u091a\u093f\u0924\u094d\u0930 \u0967<\/a>)\u0964 \u092f\u094b \u0926\u093e\u092f\u0930\u093e\u0932\u0947 \u0938\u0919\u094d\u0915\u0947\u0924 \u0917\u0930\u094d\u091b \u0915\u093f \u092c\u093f\u0930\u093e\u092e\u0940\u0932\u093e\u0908 \u092c\u0926\u093e\u092e\u0915\u094b \u090f\u0932\u0930\u094d\u091c\u0940\u0915\u094b \u0938\u092e\u094d\u092d\u093e\u0935\u0928\u093e \u0915\u092e \u091b, \u091c\u0941\u0928 OFC \u092e\u093e\u0930\u094d\u092b\u0924 \u092a\u0941\u0937\u094d\u091f\u093f \u0917\u0930\u094d\u0928 \u0938\u0915\u093f\u0928\u094d\u091b\u0964<\/p>\n<div id=\"F1\" class=\"fig pos-float  odd\">\n<div class=\"highwire-figure\">\n<div class=\"fig-inline-img-wrapper\">\n<div class=\"fig-inline-img\"><span class=\"hw-responsive-img\"><img fetchpriority=\"high\" decoding=\"async\" class=\"highwire-fragment fragment-image lazyload\" alt=\"\u091a\u093f\u0924\u094d\u0930 \u0967\" src=\"https:\/\/ep.bmj.com\/content\/edpract\/109\/5\/247\/F1.medium.gif\" width=\"280\" height=\"440\"\/><img decoding=\"async\" class=\"highwire-fragment fragment-image\" alt=\"\u091a\u093f\u0924\u094d\u0930 \u0967\" src=\"https:\/\/ep.bmj.com\/content\/edpract\/109\/5\/247\/F1.medium.gif\" width=\"280\" height=\"440\"\/><\/span><\/div>\n<\/div>\n<\/div>\n<div xmlns:xhtml=\"http:\/\/www.w3.org\/1999\/xhtml\" class=\"fig-caption\"><span class=\"fig-label\">\u091a\u093f\u0924\u094d\u0930 \u0967<\/span> <\/p>\n<p id=\"p-31\" class=\"first-child\">Fagan nomograms \u0932\u0947 IgE-\u092e\u0927\u094d\u092f\u0938\u094d\u0925\u0924\u093e \u092b\u0942\u0921 \u090f\u0932\u0930\u094d\u091c\u0940\u0915\u094b \u0938\u092e\u094d\u092d\u093e\u0935\u0928\u093e\u0915\u094b \u0915\u0932\u094d\u092a\u0928\u093e \u0917\u0930\u094d\u0928 \u0927\u0947\u0930\u0948 \u092a\u094d\u092f\u093e\u0930\u093e\u092e\u093f\u091f\u0930\u0939\u0930\u0942 \u0938\u092e\u093e\u0935\u0947\u0936 \u0917\u0930\u094d\u0926\u091b\u0964 IgE, \u0907\u092e\u094d\u092f\u0941\u0928\u094b\u0917\u094d\u0932\u094b\u092c\u0941\u0932\u093f\u0928 \u0908; LR, \u0938\u092e\u094d\u092d\u093e\u0935\u0928\u093e \u0905\u0928\u0941\u092a\u093e\u0924; \u0928\u0915\u093e\u0930\u093e\u0924\u094d\u092e\u0915, \u0928\u0915\u093e\u0930\u093e\u0924\u094d\u092e\u0915; \u0938\u094d\u0925\u093f\u0924\u093f, \u0938\u0915\u093e\u0930\u093e\u0924\u094d\u092e\u0915; \u092a\u094d\u0930\u094b\u092c, \u0938\u092e\u094d\u092d\u093e\u0935\u094d\u092f\u0924\u093e\u0964<\/p>\n<\/div>\n<\/div>\n<p id=\"p-32\">IgE- \u092e\u0927\u094d\u092f\u0938\u094d\u0925 \u0916\u093e\u0928\u093e \u090f\u0932\u0930\u094d\u091c\u0940\u0915\u094b \u0932\u093e\u0917\u093f \u092a\u0930\u0940\u0915\u094d\u0937\u0923\u0915\u094b \u0906\u0935\u0936\u094d\u092f\u0915\u0924\u093e \u092a\u0930\u0947\u0915\u093e \u092c\u093f\u0930\u093e\u092e\u0940\u0939\u0930\u0942 \u092a\u0939\u093f\u091a\u093e\u0928 \u0917\u0930\u094d\u0928, \u0938\u0939\u0940 \u092a\u0930\u0940\u0915\u094d\u0937\u0923\u0939\u0930\u0942 \u0917\u0930\u094d\u0928 \u0930 \u092a\u0930\u0940\u0915\u094d\u0937\u0923 \u092a\u0930\u093f\u0923\u093e\u092e\u0939\u0930\u0942 \u0915\u0938\u0930\u0940 \u0935\u094d\u092f\u093e\u0916\u094d\u092f\u093e \u0917\u0930\u094d\u0928\u0947 \u092d\u0928\u0947\u0930 \u091c\u093e\u0928\u094d\u0928\u0932\u0947 \u092c\u093f\u0930\u093e\u092e\u0940\u0915\u094b \u0938\u0941\u0930\u0915\u094d\u0937\u093e\u092e\u093e \u0938\u0941\u0927\u093e\u0930 \u0917\u0930\u094d\u0928 \u0930 \u0905\u0924\u094d\u092f\u0927\u093f\u0915 \u092a\u0930\u0940\u0915\u094d\u0937\u0923\u0915\u094b \u092c\u094b\u091d \u0915\u092e \u0917\u0930\u094d\u0928 \u0938\u0915\u094d\u091b \u092d\u0928\u094d\u0928\u0947 \u092c\u093e\u0930\u0947 \u0938\u0941\u0927\u093e\u0930\u093f\u090f\u0915\u094b \u0935\u094d\u092f\u0935\u0938\u093e\u092f\u0940 \u0936\u093f\u0915\u094d\u0937\u093e\u0964<\/p>\n<div class=\"boxed-text\" id=\"boxed-text-2\">\n<h3>\u0915\u094d\u0932\u093f\u0928\u093f\u0915\u0932 \u0924\u0932\u094d\u0932\u094b \u0930\u0947\u0916\u093e<\/h3>\n<ul class=\"list-unord \" id=\"list-4\">\n<li id=\"list-item-12\">\n<p id=\"p-33\">IgE- \u092e\u0927\u094d\u092f\u0938\u094d\u0925 \u0916\u093e\u0928\u093e \u090f\u0932\u0930\u094d\u091c\u0940\u0915\u094b \u0932\u093e\u0917\u093f \u092a\u0930\u0940\u0915\u094d\u0937\u0923 \u0938\u092e\u094d\u092d\u093e\u0935\u093f\u0924 \u090f\u0932\u0930\u094d\u091c\u0940 \u092a\u094d\u0930\u0924\u093f\u0915\u094d\u0930\u093f\u092f\u093e \u0926\u0947\u0916\u093e\u0909\u0928\u0947 \u091a\u093f\u0915\u093f\u0924\u094d\u0938\u093e \u0907\u0924\u093f\u0939\u093e\u0938 \u092d\u090f\u0915\u093e \u092c\u093f\u0930\u093e\u092e\u0940\u0939\u0930\u0942\u092e\u093e \u092e\u093e\u0924\u094d\u0930 \u0917\u0930\u093f\u0928\u0941\u092a\u0930\u094d\u091b\u0964<\/p>\n<\/li>\n<li id=\"list-item-13\">\n<p id=\"p-34\">\u090f\u0928\u094d\u091f\u093f\u091c\u0947\u0928-\u0935\u093f\u0936\u093f\u0937\u094d\u091f \u092a\u0930\u0940\u0915\u094d\u0937\u0923\u0939\u0930\u0942, \u091c\u0938\u094d\u0924\u0948 SPT \u0930 sIgE \u092a\u0930\u0940\u0915\u094d\u0937\u0923\u0939\u0930\u0942\u0932\u0947 \u0938\u092e\u094d\u092d\u093e\u0935\u0928\u093e \u0938\u094d\u0925\u093e\u092a\u093f\u0924 \u0917\u0930\u094d\u0928 \u0938\u0915\u094d\u091b\u0928\u094d\u0964<\/p>\n<\/li>\n<li id=\"list-item-14\">\n<p id=\"p-35\">OFC IgE- \u092e\u0927\u094d\u092f\u0938\u094d\u0925 \u0916\u093e\u0928\u093e \u090f\u0932\u0930\u094d\u091c\u0940\u0915\u094b \u0928\u093f\u0926\u093e\u0928 \u092a\u0941\u0937\u094d\u091f\u093f \u0917\u0930\u094d\u0928\u0915\u094b \u0932\u093e\u0917\u093f \u0938\u0941\u0928\u0915\u094b \u092e\u093e\u0928\u0915 \u0939\u094b\u0964<\/p>\n<\/li>\n<li id=\"list-item-15\">\n<p id=\"p-36\">IgE-\u092e\u0927\u094d\u092f\u0938\u094d\u0925\u0924\u093e \u092b\u0942\u0921 \u090f\u0932\u0930\u094d\u091c\u0940 \u092a\u0930\u0940\u0915\u094d\u0937\u0923\u0915\u094b \u0905\u0924\u094d\u092f\u0927\u093f\u0915 \u092a\u094d\u0930\u092f\u094b\u0917\u0932\u0947 \u0905\u0924\u094d\u092f\u0927\u093f\u0915 \u0928\u093f\u0926\u093e\u0928, \u0905\u0928\u093e\u0935\u0936\u094d\u092f\u0915 \u0906\u0939\u093e\u0930 \u092a\u094d\u0930\u0924\u093f\u092c\u0928\u094d\u0927 \u0930 \u092e\u0928\u094b\u0938\u093e\u092e\u093e\u091c\u093f\u0915 \u0930 \u0906\u0930\u094d\u0925\u093f\u0915 \u092c\u094b\u091d \u0928\u093f\u092e\u094d\u0924\u094d\u092f\u093e\u0909\u0901\u091b\u0964<\/p>\n<\/li>\n<\/ul>\n<\/div>\n<div class=\"boxed-text\" id=\"boxed-text-3\">\n<h3>\u0906\u092b\u094d\u0928\u094b \u091c\u094d\u091e\u093e\u0928 \u092a\u0930\u0940\u0915\u094d\u0937\u0923 \u0917\u0930\u094d\u0928\u0941\u0939\u094b\u0938\u094d<\/h3>\n<ol class=\"list-ord \" id=\"list-5\">\n<li id=\"list-item-16\">\n<p id=\"p-37\">\u0928\u093f\u092e\u094d\u0928 \u0916\u093e\u0926\u094d\u092f \u090f\u0932\u0930\u094d\u091c\u0940\u0939\u0930\u0942 \u092e\u0927\u094d\u092f\u0947, \u0915\u0941\u0928 \u0906\u0920 \u0938\u092c\u0948\u092d\u0928\u094d\u0926\u093e \u0938\u093e\u092e\u093e\u0928\u094d\u092f \u0916\u093e\u0928\u093e \u090f\u0932\u0930\u094d\u091c\u0940\u0939\u0930\u0942 \u092e\u0927\u094d\u092f\u0947 \u090f\u0915 \u0939\u094b\u0907\u0928?<\/p>\n<ol class=\"list-alphaupper \" id=\"list-6\">\n<li id=\"list-item-17\">\n<p id=\"p-38\">\u0938\u094b\u092f\u093e<\/p>\n<\/li>\n<li id=\"list-item-18\">\n<p id=\"p-39\">\u0917\u0939\u0941\u0901<\/p>\n<\/li>\n<li id=\"list-item-19\">\n<p id=\"p-40\">\u091a\u0915\u0932\u0947\u091f<\/p>\n<\/li>\n<li id=\"list-item-20\">\n<p id=\"p-41\">\u0926\u0942\u0927<\/p>\n<\/li>\n<\/ol>\n<\/li>\n<li id=\"list-item-21\">\n<p id=\"p-42\">\u0924\u0932\u0915\u093e \u092e\u0927\u094d\u092f\u0947 \u0915\u0941\u0928 \u092a\u0930\u0940\u0915\u094d\u0937\u0923\u0932\u0947 IgE- \u092e\u0927\u094d\u092f\u0938\u094d\u0925 \u0916\u093e\u0928\u093e \u090f\u0932\u0930\u094d\u091c\u0940\u0915\u094b \u092c\u0922\u094d\u0926\u094b \u0938\u092e\u094d\u092d\u093e\u0935\u0928\u093e \u092a\u0939\u093f\u091a\u093e\u0928 \u0917\u0930\u094d\u091b?<\/p>\n<ol class=\"list-alphaupper \" id=\"list-7\">\n<li id=\"list-item-22\">\n<p id=\"p-43\">\u0916\u093e\u0926\u094d\u092f \u0938\u0902\u0935\u0947\u0926\u0928\u0936\u0940\u0932\u0924\u093e \u092a\u0930\u0940\u0915\u094d\u0937\u0923<\/p>\n<\/li>\n<li id=\"list-item-23\">\n<p id=\"p-44\">SPT<\/p>\n<\/li>\n<li id=\"list-item-24\">\n<p id=\"p-45\">\u0938\u093e\u0907\u091f\u094b\u091f\u094b\u0915\u094d\u0938\u093f\u0938\u093f\u091f\u0940 \u092a\u0930\u0940\u0915\u094d\u0937\u0923<\/p>\n<\/li>\n<li id=\"list-item-25\">\n<p id=\"p-46\">\u0915\u092a\u093e\u0932 \u0935\u093f\u0936\u094d\u0932\u0947\u0937\u0923<\/p>\n<\/li>\n<\/ol>\n<\/li>\n<li id=\"list-item-26\">\n<p id=\"p-47\">\u0915\u0941\u0928 \u092c\u093e\u0939\u094d\u092f \u0915\u093e\u0930\u0915\u0939\u0930\u0942\u0932\u0947 sIgE \u0938\u094d\u0924\u0930\u0939\u0930\u0942\u0932\u093e\u0908 \u0905\u0938\u0930 \u0917\u0930\u094d\u0928 \u0938\u0915\u094d\u091b?<\/p>\n<ol class=\"list-alphaupper \" id=\"list-8\">\n<li id=\"list-item-27\">\n<p id=\"p-48\">\u0909\u092e\u0947\u0930<\/p>\n<\/li>\n<li id=\"list-item-28\">\n<p id=\"p-49\">\u092d\u094c\u0917\u094b\u0932\u093f\u0915 \u0938\u094d\u0925\u093e\u0928<\/p>\n<\/li>\n<li id=\"list-item-29\">\n<p id=\"p-50\">\u090f\u0932\u0930\u094d\u091c\u0940 \u0930\u094b\u0917\u0939\u0930\u0942<\/p>\n<\/li>\n<li id=\"list-item-30\">\n<p id=\"p-51\">\u092e\u093e\u0925\u093f\u0915\u093e \u0938\u092c\u0948<\/p>\n<\/li>\n<\/ol>\n<\/li>\n<li id=\"list-item-31\">\n<p id=\"p-52\">\u092f\u0926\u093f \u092c\u093f\u0930\u093e\u092e\u0940\u0915\u094b \u0907\u0924\u093f\u0939\u093e\u0938 SPT \u0928\u0924\u093f\u091c\u093e\u0938\u0901\u0917 \u092c\u0947\u092e\u0947\u0932 \u091b \u092d\u0928\u0947, \u0916\u093e\u0928\u093e\u0915\u094b \u090f\u0932\u0930\u094d\u091c\u0940 \u092a\u0941\u0937\u094d\u091f\u093f \u0917\u0930\u094d\u0928 \u0935\u093e \u0905\u0938\u094d\u0935\u0940\u0915\u093e\u0930 \u0917\u0930\u094d\u0928 \u0915\u0941\u0928 \u092a\u0930\u0940\u0915\u094d\u0937\u0923 \u092a\u094d\u0930\u092f\u094b\u0917 \u0917\u0930\u093f\u0928\u094d\u091b?<\/p>\n<ol class=\"list-alphaupper \" id=\"list-9\">\n<li id=\"list-item-32\">\n<p id=\"p-53\">\u0905\u0930\u094d\u0915\u094b SPT<\/p>\n<\/li>\n<li id=\"list-item-33\">\n<p id=\"p-54\">sIgE \u092a\u094d\u092f\u093e\u0928\u0932<\/p>\n<\/li>\n<li id=\"list-item-34\">\n<p id=\"p-55\">OFC<\/p>\n<\/li>\n<li id=\"list-item-35\">\n<p id=\"p-56\">\u0915\u092e\u094d\u092a\u094b\u0928\u0947\u0928\u094d\u091f \u092a\u0930\u0940\u0915\u094d\u0937\u0923<\/p>\n<\/li>\n<\/ol>\n<\/li>\n<\/ol>\n<p id=\"p-57\">\n<em>\u092a\u094d\u0930\u0936\u094d\u0928\u094b\u0924\u094d\u0924\u0930\u0940\u0915\u093e \u0909\u0924\u094d\u0924\u0930\u0939\u0930\u0942 \u0938\u0928\u094d\u0926\u0930\u094d\u092d\u0915\u094b \u0905\u0928\u094d\u0924\u094d\u092f\u092e\u093e \u091b\u0928\u094d\u0964<\/em>\n<\/p>\n<\/div>\n<div class=\"boxed-text\" id=\"boxed-text-4\">\n<h3>\u092c\u0939\u0941\u0935\u093f\u0915\u0932\u094d\u092a\u0940\u092f \u092a\u094d\u0930\u0936\u094d\u0928\u0939\u0930\u0942\u0915\u094b \u091c\u0935\u093e\u092b<\/h3>\n<ol class=\"list-ord \" id=\"list-10\">\n<li id=\"list-item-36\">\n<p id=\"p-58\">\u0938\u0940\u0964<\/p>\n<\/li>\n<li id=\"list-item-37\">\n<p id=\"p-59\">\u092c\u093f.<\/p>\n<\/li>\n<li id=\"list-item-38\">\n<p id=\"p-60\">D.<\/p>\n<\/li>\n<li id=\"list-item-39\">\n<p id=\"p-61\">\u0938\u0940\u0964<\/p>\n<\/li>\n<\/ol>\n<\/div>\n<\/div>\n<div class=\"section ethics-statement\" id=\"sec-14\">\n<h2 class=\"\">\u0928\u0948\u0924\u093f\u0915\u0924\u093e \u0915\u0925\u0928\u0939\u0930\u0942<\/h2>\n<div class=\"section\" id=\"sec-15\">\n<h3>\u092a\u094d\u0930\u0915\u093e\u0936\u0928\u0915\u094b \u0932\u093e\u0917\u093f \u092c\u093f\u0930\u093e\u092e\u0940\u0915\u094b \u0938\u0939\u092e\u0924\u093f<\/h3>\n<p id=\"p-66\" class=\"ethics-consent-to-publish\">\u0932\u093e\u0917\u0942 \u0939\u0941\u0901\u0926\u0948\u0928\u0964<\/p>\n<\/div>\n<\/div>\n<div class=\"section ack\" id=\"ack-1\">\n<h2>\u0938\u094d\u0935\u0940\u0915\u0943\u0924\u093f\u0939\u0930\u0942<\/h2>\n<p id=\"p-62\">\u0932\u0947\u0916\u0915\u0939\u0930\u0942 \u091c\u0930\u094d\u091c \u0921\u0941 \u091f\u094b\u0907\u091f, MMeD, \u092a\u093e\u0923\u094d\u0921\u0941\u0932\u093f\u092a\u093f \u0935\u093f\u0915\u093e\u0938\u0915\u094b \u0915\u094d\u0930\u092e\u092e\u093e \u0909\u0928\u0915\u094b \u092f\u094b\u0917\u0926\u093e\u0928\u0915\u094b \u0932\u093e\u0917\u093f \u0927\u0928\u094d\u092f\u0935\u093e\u0926\u0964 \u091a\u093f\u0915\u093f\u0924\u094d\u0938\u093e \u0932\u0947\u0916\u0928 \u0938\u092e\u0930\u094d\u0925\u0928 \u091c\u0947\u0928\u0940 \u091c\u094b\u0928\u094d\u0938\u0928, \u092a\u0940\u090f\u091a\u0921\u0940, \u0908\u090f\u0932\u090f\u0938, \u0930 \u091c\u0947\u0928\u094d\u0928\u093e \u0932\u0941\u0907\u0938, \u090f\u092e\u090f, \u0908\u090f\u0932\u090f\u0938, \u092e\u0947\u0921\u0925\u093f\u0902\u0915 \u0938\u093e\u0907\u0915\u092e \u0926\u094d\u0935\u093e\u0930\u093e \u092a\u094d\u0930\u0926\u093e\u0928 \u0917\u0930\u093f\u090f\u0915\u094b \u0925\u093f\u092f\u094b\u0964<\/p>\n<\/div>\n<p><span class=\"highwire-journal-article-marker-end\"\/><\/div>\n<p><a href=\"http:\/\/ep.bmj.com\/cgi\/content\/short\/109\/5\/247?rss=1\">Source link <\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u092a\u0930\u093f\u091a\u092f \u092a\u094d\u0930\u0924\u093f\u0915\u0942\u0932 \u0916\u093e\u0926\u094d\u092f \u092a\u094d\u0930\u0924\u093f\u0915\u094d\u0930\u093f\u092f\u093e\u0939\u0930\u0942\u0932\u093e\u0908 \u0935\u094d\u092f\u093e\u092a\u0915 \u0930\u0942\u092a\u092e\u093e \u092a\u094d\u0930\u0924\u093f\u0930\u0915\u094d\u0937\u093e-\u092e\u0927\u094d\u092f\u0938\u094d\u0925\u0924\u093e \u0930 \u0917\u0948\u0930-\u092a\u094d\u0930\u0924\u093f\u0930\u0915\u094d\u0937\u093e-\u092e\u0927\u094d\u092f\u0938\u094d\u0925\u0924\u093e \u092a\u094d\u0930\u0924\u093f\u0915\u094d\u0930\u093f\u092f\u093e\u0939\u0930\u0942\u092e\u093e \u0935\u0930\u094d\u0917\u0940\u0915\u0943\u0924 \u0917\u0930\u094d\u0928 \u0938\u0915\u093f\u0928\u094d\u091b, \u0936\u093e\u0938\u094d\u0924\u094d\u0930\u0940\u092f \u0916\u093e\u0926\u094d\u092f \u090f\u0932\u0930\u094d\u091c\u0940 \u092a\u094d\u0930\u0924\u093f\u0930\u0915\u094d\u0937\u093e \u092e\u0927\u094d\u092f\u0938\u094d\u0925\u0924\u093e\u0915\u094b \u0938\u093e\u0925\u0964\u0967 \u0907\u092e\u094d\u092f\u0941\u0928\u094b\u0917\u094d\u0932\u094b\u092c\u0941\u0932\u093f\u0928 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":245,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[8],"tags":[],"class_list":["post-252","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-education"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v23.2 (Yoast SEO v26.9) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>IgE- \u092e\u0927\u094d\u092f\u0938\u094d\u0925 \u0916\u093e\u0928\u093e \u090f\u0932\u0930\u094d\u091c\u0940 \u0915\u0938\u0930\u0940 \u0928\u093f\u0926\u093e\u0928 \u0917\u0930\u094d\u0928\u0947 - Harit Thakuri<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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\u0917\u0948\u0930-\u092a\u094d\u0930\u0924\u093f\u0930\u0915\u094d\u0937\u093e-\u092e\u0927\u094d\u092f\u0938\u094d\u0925\u0924\u093e \u092a\u094d\u0930\u0924\u093f\u0915\u094d\u0930\u093f\u092f\u093e\u0939\u0930\u0942\u092e\u093e \u0935\u0930\u094d\u0917\u0940\u0915\u0943\u0924 \u0917\u0930\u094d\u0928 \u0938\u0915\u093f\u0928\u094d\u091b, \u0936\u093e\u0938\u094d\u0924\u094d\u0930\u0940\u092f \u0916\u093e\u0926\u094d\u092f \u090f\u0932\u0930\u094d\u091c\u0940 \u092a\u094d\u0930\u0924\u093f\u0930\u0915\u094d\u0937\u093e \u092e\u0927\u094d\u092f\u0938\u094d\u0925\u0924\u093e\u0915\u094b \u0938\u093e\u0925\u0964\u0967 \u0907\u092e\u094d\u092f\u0941\u0928\u094b\u0917\u094d\u0932\u094b\u092c\u0941\u0932\u093f\u0928 [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/hthakuri.com.np\/blog\/2024\/09\/26\/ige-\u092e\u0927\u094d\u092f\u0938\u094d\u0925-\u0916\u093e\u0928\u093e-\u090f\u0932\u0930\u094d\u091c\u0940-\u0915\u0938\u0930\u0940\/\" \/>\n<meta property=\"og:site_name\" content=\"Harit Thakuri\" \/>\n<meta property=\"article:published_time\" content=\"2024-09-26T13:47:46+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/ep.bmj.com\/content\/edpract\/109\/5\/247\/F1.medium.gif\" \/>\n<meta name=\"author\" content=\"Harit Thakuri\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Harit Thakuri\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" 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